Search
Now showing items 1-10 of 13
Innate and acquired immunity to Leishmania in humans : the role of the host versus the parasite
(1999-10-01)
Leishmania are intracellular protozoan parasites of macrophages which induce chronic diseases in man. The study of this parasite has been instrumental in elucidating many facets of the immune system. Our study set out to ...
Synaptic vesicle endocytosis studied in a living synapse
(2000-09-29)
Neurons in the central nervous system communicate by transmitting electrical signals at special sites of contact called synapses. Synapses contain neurotransmitter-filled synaptic vesicles, which fuse with the presynaptic ...
Molecular regulation and analysis of neural stem and cancer cell characteristics
(2012-05-25)
Every single cell within an organism is constantly facing the demanding task of preserving the integrity of its genomic material to secure proper function and clearance from disease. To accomplish this cells rely on DNA ...
Understanding preclinical dementia : early detection of dementia through cognitive and biological markers
(2020-09-14)
three modalities: hippocampal volume, a task of category fluency, presence of an APOE ɛ4 allele, white-matter hyperintensities volume, and a task of general knowledge, displayed the most predictive value (AUC=.924; C.I=.883–.965). However, this model did...
Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments
(2011-12-21)
, IGFBP-2 and IGFBP-4. IGFBP-1 bound to IGF-I was also degraded whereas IGF-II was shown to have an inhibitory effect on proteolysis of IGFBP-1. The proteolytically active preparation of neutrophil-derived azurocidin was found to be glycosylated...
Translational genomics of HIV-1 subtype C in India : molecular phylogeny and drug resistance
(2013-05-16)
-cell counts. In addition, older children with HIV-1 subtype C infection presented a high prevalence of predicted X4 and R5/X4 tropic strains which indicates that HIV-1 subtype C strains required longer duration of infection and greater disease progression...
Assays for monitoring HIV therapy in low-middle income countries
(2013-05-20)
The purpose of this thesis was to develop and/or evaluate assays for HIV viral load (VL) monitoring and HIV drug resistance testing of potential importance for research studies and clinical care in low- and middle income ...
Recurrent abdominal pain in children : the concept, aetiology, diagnostics and prognosis
(2018-08-10)
. In study I, 258 children 4-17 years old seeking care for gastrointestinal complaints were evaluated. Validated Rome III based patient-administered symptom questionnaires were filled in at the initial visit, blinded to the clinician. One year after inclusion...
Heart failure : role of metabolic biomarkers, ejection fraction, and sex
(2018-10-30)
Background: Heart failure (HF) is common and associated with impaired quality of life (QoL) and poor prognosis. There is a ternary classification of HF based on ejection fraction (EF): HF with preserved(HFpEF), mid-range ...
Roles of Myc and Mad in cell cycle and apoptosis
(2006-05-12)
The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptosis. They are basic region hehx-loop-helix/leucine zipper (bHLH/Zip) transcription factors that require hetero-dimerization ...