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Studies on 5-hydroxytryptophol and the metabolic interaction between serotonin and ethanol
(1999-11-16)
-hydroxytryptophol (5HTOL) by alcohol dehydrogenase (ADH). Acute ethanol intake alters the metabolic conversion of 5HIAL from the oxidative toward the reductive pathway resulting in an elevated 5HTOL/5H1AA ratio. After ethanol has been eliminated from the body...
Measuring brain functions : statistical tests for neuroimaging data
(2001-08-31)
This thesis is about statistical methods for functional neuroimaging
data. With functional neuroimaging, here understood as PET and fMRI, the
activity of the human brain can be studied in vivo. The statistical
methods ...
Studies on ribonucleotide reductase, a target for anticancer therapy, with focus on electron donor aspects : thioredoxin and glutaredoxin systems
(2009-03-27)
Faithful replication of DNA and its repair are fundamental processes in
all living cells which utilize deoxyribonucleotides as DNA building
blocks. Ribonucleotide reductase (RNR) is the essential enzyme for de
novo ...
Patients with head and neck cancer : aspects on treatment, complications and rehabilitation
(2010-11-15)
Head and neck cancer is reported to be the fifth most common cancer globally and around 1,200 new patients are diagnosed in Sweden every year. Historically, survival rates have been rather constant but have started to improve over the last few...
Interstitial lung disease in polymyositis and dermatomyositis
(2006-11-17)
. The number of patients with ILD had been even higher with the use of bronchoscopy and BAL, as alveolitis was also evident in patients without evidence of ILD through radiographic examinations or lung function tests. Arthritis and positive anti-Jo-1...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Generation and investigation of neural microenvironment in health and disease
(2019-10-09)
neural stem cells (NSCs). By applying different metabolic conditions in vitro, we showed that hypoxia and 2-Deoxy-D-glucose increased acetylation of CtBP2 in proliferating NSCs. Additionally, 1% oxygen treatment resulted in altered homodimerization of Ct...
Rheumatoid arthritis : pharmacological modulation of cytokines : aspects of clinical response and endocrine regulation
(2006-01-06)
-antagonists on cytokine expression in the synovial membrane may be of relevance as additional therapeutic targets may be identified. We studied the effect of the TNF-antagonist infliximab on the synovial expression of TNF, IL-1alpha, IL-1beta, IFNgamma and IL-15...
Molecular mechanisms in synaptic vesicle recycling
(2010-09-03)
Neurons communicate through specialized contacts called synapses, which consist of pre- and postsynaptic compartments separated by a narrow synaptic cleft. The stimulus- dependent rapid influx of calcium ions into the ...
Nucleic acid in gene delivery and gene regulation
(2011-08-01)
The concept of gene therapy, initially attributed to a technology that would allow the correction of inherited genetic disease, has evolved over the years. The realization of the immense technical hurdles to achieve genetic ...