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Characterization of candidate disease genes from human chromosomes 11g13 and 22q
(1999-10-28)
Two regions of the human genome, 11q13 and 22q, have been shown to harbor numerous disease-related genes, among them tumor suppressor genes (TSGs). The aim of this project was to construct transcription maps within these ...
Molecular regulation and analysis of neural stem and cancer cell characteristics
(2012-05-25)
and multipotency required for differentiation into the various cell lineages found in the mammalian CNS. Further, we show that NEIL3 deficiency can enhance formation of senescence related heterochromatin foci, suggesting an influence in regulatory functions...
Interventions during pregnancy and labor and obstetric outcome
(2011-09-16)
cesarean section among women who were induced to labor in gestational week ≥41 and to evaluate if parity and mode of induction affected this association, and 3) to analyze if starting time for labor induction affected the risk of night-time delivery...
Natural killer cells in cancer : studies on migration and cytotoxicity
(2014-05-08)
allowed them to migrate towards tumor cells in a CXCL10-dependent manner. In two separate xenograft models we could demonstrate the anti-tumor effect of CXCL10-induced migration of adoptively transferred CXCR3-positive NK cells by their selective targeting...
Hormones, muscles and oncological outcome in men with rectal cancer
(2019-10-04)
in muscle areas of the lower trunk and pelvis. The estimated change (95% CI) of muscle area increase per 100 mg of T enanthate dosage increase was 0.622 cm2 (0.394, 0.850) for psoas; 1.789 cm2 (1.317, 2.261) for paraspinal muscles; 2.530 cm2 (1.627, 3...
Studies on anti-inflammatory and vasoactive effects of mPGES-1 inhibition
(2022-12-13)
and metabolism of 15dPGJ2 via conjugation to glutathione in immune cells and upon inhibition of mPGES-1. The results of this study demonstrate the formation of 15dPGJ2-glutathione and 15dPGJ2-cysteine conjugates in immune cells, the involvement of MGST3...
Exosomes : the future of vaccination?
(2011-11-25)
to increase immunogenicity of exosomes, and 3) studying the relevance of exosomes in a human inflammatory disease, atopic eczema (AE). We report that exosomes from murine bone marrow-derived dendritic cells (DCs) can induce CD4+ T cell responses in a B cell...
Exosomes : immunomodulators in cancer and therapy
(2016-08-30)
Exosomes are nano-sized membrane vesicles derived from the late endosomal compartment. They are capable of transferring proteins, lipids and RNA between cells. B cell and dendritic cell (DC)-derived exosomes express major ...
Exploring immunotherapeutic targets in the tumor microenvironment
(2015-11-19)
The immune system has developed along with the evolution of increasingly complex
cellular organisms to sustain homeostasis and protect from threats. Cancer, a detrimental
side effect of increasing organismic complexity, ...
Female autism phenotypes : sex/gender differences in functioning, camouflaging, and eating problems
(2023-05-02)
Background: Autism is a neurodevelopmental condition defined by challenges in social interaction and communication and presence of repetitive patterns in behavior, interests, and activities alongside sensory processing ...