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Suppressive DNA vaccination in experimental autoimmune encephalomyelitis
(1999-11-26)
)-EAE. Vaccination with DNA encoding MOG91-108 suppressed clinical signs of EAE, after MOG91-108-challenge.
In conclusion, vaccination with DNA encoding autoantigenic peptides suppresses EAE. Presence of ISS and a local type 1 cytokine milieu is decisive...
On innate behaviors : focus on parental behavior and aggression
(2018-10-26)
The neural substrates orchestrating a number of social behaviors, including parental behavior and aggression, are known to exist in the hypothalamus. Through the control of the pituitary gland, the hypothalamus regulates ...
Using enriched quality register data for health care evaluation : examples from rheumatoid arthritis
(2014-09-24)
Swedish registers have for decades successfully been used for medica research, enabling long-term follow-up of large patient cohorts using observational designs. With a tax funded health care system and the use of a personal ...
Oxidoreductases and RNA degradosome controlling virulence-associated traits of Salmonella enterica serovar Typhimurium
(2013-09-04)
The oxidative stress response is a fundamental and primitive mode of innate immune defense in nearly all forms of life. The host oxidative stress response becomes truly important and effective especially against intracellular ...
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(2020-10-07)
In the last decade the treatment of metastatic melanoma (MM) has been revolutionized and changed the life of many patients, offering prolonged survival and improved symptom control. These treatment strategies have also ...
The development of psychiatric disorders and adverse behaviors : from context to prediction
(2022-01-28)
Psychiatric disorders by definition cause significant impairment in an individual’s daily functioning. Certain disorders, such as borderline personality disorder (BPD) and eating disorders, have worse prognosis and high ...
Diversity and function of anti-modified protein autoantibodies in rheumatoid arthritis
(2022-11-10)
Rheumatoid arthritis (RA) is a chronic autoimmune disease particularly affecting synovial joints. Anti-citrullinated protein autoantibodies (ACPA) are detected in the serum of about 2/3 of RA patients and are being used ...
Advancing cancer immunotherapy by exploring NK cell education, antibody targeting and tissue homing : stay tuned for directions reaching beyond the natural biology
(2022-10-21)
Cancer immunotherapy is a fast-growing field. The natural killer (NK) cells’ innate ability to detect malignant cells and capacity to perform antibody-dependent cellular cytotoxicity (ADCC) together with low risk of inducing ...
Vaccination against Her2/neu : expressing cancer using chimeric virus-like particles
(2009-04-24)
Thanks to the development of vaccines, children are these days protected
against infectious diseases like polio, diphtheria and tetanus simply by
receiving a few injections. Imagine a scenario where these injections
would ...
Dynamics of proteinopathies in Alzheimer’s disease as measured by PET and CSF biomarkers
(2018-10-05)
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the extracellular aggregation of the amyloid-β (Aβ; amyloid) peptide and the intraneuronal accumulation of the protein tau. Independently, and in ...