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Afferent input to midbrain dopamine neurones and its modulation : an electrophysiological study i vitro
(1999-09-24)
excitatory postsynaptic event that was blocked by application of the NMDA antagonist AP5. Moreover, the amplitude of the slow postsynaptic event was markedly reduced by L-type Ca2+ channel blockers such as nifedipine. Specific agonists to group I, II and III...
Studies of changes in volume in right ventricle with electrical bio impedance
(2002-12-12)
In intracardiac impedance, electrical bio-impedance is measured inside the heart. This signal is known to reflect the volume of blood passing in and out of the ventricles. In transthoracic impedance the measurement current ...
Functional analysis of long non-coding RNAs in cancer
(2017-11-24)
For years the functional role of noncoding RNAs was greatly underestimated. Whole genome RNA sequencing projects that unraveled pervasive transcription emitting from large parts of the human genome changed those perspectives ...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice
(2016-08-10)
Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and ...
Characterization of B cell response alterations resulting from ablation of IκBNS expression
(2020-08-07)
identified a precursor population in wildtype mice of IgM+CD93+CD19+CD5+ transitional B1a cells (TrB-1a), which exhibited other indicators of B-1 lineage commitment, such as natural IgM secretion and increased Igλ expression. We did not detect TrB-1a cells...
Physiological status of bacteria used for environmental applications
(2006-12-22)
bacterial
luciferase) or luc (encoding eukaryotic luciferase). Viability stains,
5-cyano-2,3-ditolyl-tetrazolium chloride (CTC) and propidium iodide (PI),
were used to stain active and dead cells, respectively. The marker-gene
tagged cells were incubated...
Novel in vitro methods aiming at improving fertility preservation
(2021-11-11)
The well-established fertility preservative methods for female cancer patients include the cryopreservation of embryos, mature oocytes and ovarian tissue before the initiation of gonadotoxic cancer treatment. Due to a ...
Factors associated with lung function impairment in children and adults with obstructive lung disease
(2008-05-14)
Obstructive lung diseases are a group of diseases in which there is a limitation in the flow of air into or out of the lungs. Two common such diseases are asthma, which is found in both children and adults, and chronic ...
Clinical studies of glucose variability and hypoglycemia in adult patients with type 1 diabetes
(2011-11-02)
with CSII, 9.11 vs. 10.31 (p=0.002). There was an average of 1.3 more episodes of values below 3.5 mmol/l with CSII (p=0.053). There were no significant differences in glucose variability measured as SDPG or the mean amplitude of glucose excursions (MAGE...