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Regional ventilation, pulmonary perfusion and gas exchange in supine and prone positions
(1999-10-29)
The rationale for treating patients with acute lung injury in the prone position springs from a number of observations. Clinical reports have documented improved oxygenation when patients are turned prone. Regional vascular ...
The role of neuropeptides in spinal nociceptive mechanisms with special emphasis on galanin, neuropeptide Y and orphanin FQ/nociceptin
(2000-01-21)
Several peptides present in sensory neurons and in the spinal cord have been recognized to have inhibitory action in nociception. In this thesis, we have used the flexor reflex preparation in rats to study the role of ...
Breathe (in the air) : pulmonary immunology in multiple sclerosis
(2018-02-28)
Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system, with etiology still unknown. MS is thought to arise from a complex interplay between genetic and environmental factors. One of the most well ...
Global regulation of gene expression in stem cells and regeneration
(2017-08-17)
Rapid developments in genomics and transcriptomics fields have made it possible to ask new questions as well as solve various old problems in biology that were not achievable previously. Novel techniques such as RNA ...
Modulating chromatin by transcription and nucleosome turnover : a genome-wide study in fission yeast
(2015-12-10)
Eukaryotic DNA is wrapped around histone proteins to form a nucleosome, the basic
structural unit of chromatin. Multiple levels of chromatin organization are required to
compact DNA into chromosomes, to ensure an accurate ...
Determination of transcription factor binding specificities
(2015-11-19)
The term "genetic code" refers to the way in which the information encoded in nucleic acids
is converted into the amino-acid sequence of proteins. There is however also a second genetic
code, one that is used by the cells ...
p53 guardian of the genome and target for improved treatment of leukemia
(2007-03-02)
P53 acts in several cellular processes as cell cycle checkpoints, DNA
repair senescence and the surveillance of genomic integrity. Wt p53
inhibits cancer processes by causing cell cycle arrest and apoptosis. P53
is ...
Elevated fasting glucose levels in obese children and adolescents : prevalence and long-term consequences
(2016-01-29)
Background: Obesity in childhood and adolescents is a major concern in Sweden, as in many parts of the world. Already during the pediatric years is obesity associated with several metabolic complications, which often ...
Regulators of angiogenesis in diabetes and tumors
(2005-11-21)
Angiogenesis is tightly regulated in order to provide adequate supply of nutrients and oxygen for normal cellular function. Tissue oxygenation represents a balance between the requirement for oxygen to maintain the cellular ...
Oxidoreductases and RNA degradosome controlling virulence-associated traits of Salmonella enterica serovar Typhimurium
(2013-09-04)
The oxidative stress response is a fundamental and primitive mode of innate immune defense in nearly all forms of life. The host oxidative stress response becomes truly important and effective especially against intracellular ...