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Etiological insights into the testicular cancer epidemic
(1999-08-20)
The aim of this thesis was to search for causes of the testicular cancer epidemic through epidemiologic studies of testicular cancer and possibly related conditions, such as urogenital birth defects and subfertility.
First, ...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...
Improved surgical treatment of oesophageal cancer
(2021-08-20)
Oesophageal cancer is the 7thmost common cancer globally and the 5-year survival is poor (below 20%). Curative treatment usually involves surgical resection of the tumour (oesophagectomy), with or without neoadjuvant chemo(radio)therapy. The aim...
Molecular epidemiology of tuberculosis
(2011-11-09)
Tuberculosis is a global epidemic, with one third of the world’s population estimated to be infected, around 9 million new active cases per year and close to 2 million deaths per year. Without adequate chemotherapy ...
To cut or not to cut? Episiotomy in vacuum extraction
(2022-04-05)
). After statistical balancing using propensity score, episiotomy was associated with a reduction in OASIS from 15.5% to 11.8%, ie an average treatment effect -3.7% (95% CI -4.3 to -3.0). The numbers needed to treat (NNT) to prevent one OASIS was 27...
Infectious diseases in returning Swedish travellers
(2009-09-24)
compiled information from Swedish soldiers (7,000 person months) in Liberia. The majority (81%) of the soldiers took mefloquine and the remaining part atovaquone/proguanil. After return to Sweden all soldiers completed a questionnaire about behavior and AE...
Dysglycaemia and cardiovascular disease. Aspects on screening, management, and prognosis
(2023-03-24)
Background: Dysglycaemia, in this thesis defined as impaired glucose tolerance (IGT) or type 2 diabetes (T2DM), is a major risk factor for cardiovascular disease (CVD). International guidelines recommend screening for ...
Vaccination against Her2/neu : expressing cancer using chimeric virus-like particles
(2009-04-24)
Thanks to the development of vaccines, children are these days protected
against infectious diseases like polio, diphtheria and tetanus simply by
receiving a few injections. Imagine a scenario where these injections
would ...
Causes and mechanisms of an adverse outcome in patients with glucose abnormalities and cardiovascular disease : epidemiological and biochemical analyses
(2016-10-26)
314 served as controls in the DIGAMI-study. During a mean follow-up of 7.3 years 90% of the study population died. The median survival was 2.3 years longer in patients receiving intensified insulin-based glycaemic control after AMI (7.0 years) compared...
Genetic and epigenetic factors shaping the transcriptome in multiple sclerosis and its animal model
(2014-11-21)
Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. Susceptibility to develop MS is determined by both genetic and environmental factors. The epigenome resides in the ...