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Immune and autoimmune responses to HIV-1 in mucosa and other tissues
(1999-10-08)
The aim of these studies was to evaluate routes and devices for administration of HIV-1 DNA vaccines. In particular we were interested in mucosal routes for the induction of immunity at mucosal surfaces.
We studied ...
Role of p70 S6 kinase in the formation of tau pathologies in Alzheimer’s disease
(2005-08-10)
One of the important neuropathological features of Alzheimer's disease (AD) is the tau pathology seen as accumulation and hyperphosphorylation of this protein. Evidences showed that tau could be phosphorylated mostly at ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Insulin-like growth factor 1 receptor, novel functions and future possibilities
(2017-09-01)
Insulin like growth factor-1 receptor (IGF-1R) has been shown to be important for cancer cell growth and survival, and is often overexpressed in malignant and premalignant tissues. Ligand binding to IGF-1R induces ...
Oxygen sensing in myeloid cells : implications for physiology and cancer
(2020-07-31)
All mammals depend on oxygen in order to produce life-essential energy. They acquire oxygen (O₂) through inspiration. In the lungs, O₂ is gathered by erythrocytes that consequently deliver it to all cells by the cardiovascular ...
Cellular mechanisms of human muscle fatigue and disease-related loss of muscle function
(2020-08-27)
A loss of skeletal muscle function and mass is a hallmark of several diseases resulting in a dismal life quality and poor prognosis. Impaired intracellular Ca2+-handling has been proposed as an underlying cause of these ...
Functional role of cerebrospinal fluid contacting cells in the spinal cord and hypothalamus
(2017-01-12)
Cerebrospinal fluid-contacting (CSF-c) cells are found lining the walls of the central canal and the ventricles throughout the vertebrate phylum, but their function has remained elusive. The aim here was to investigate the ...
Genetic and epigenetic factors shaping the transcriptome in multiple sclerosis and its animal model
(2014-11-21)
Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. Susceptibility to develop MS is determined by both genetic and environmental factors. The epigenome resides in the ...
Pharmacoepidemiologic studies of drug safety in pediatric chronic inflammatory disease
(2021-05-26)
Safety evidence for use of pharmaceutical drugs in children, including treatments for serious conditions such as chronic inflammatory diseases, is generally scarce. Off-label use is common and clinicians need to rely on ...
Investigating the role of p73 proteins in controlling the tumor microenvironment
(2020-10-20)
Cancer is a multifactorial disease governed by oncogenes and tumor suppressors that not only impact on the behavior of the cancer cells but also influence many processes in the surrounding tumor microenvironment. The most ...