Search
Now showing items 1-10 of 15
A microcell hybrid based 'elimination test' in the search for malignancy related genes
(1997-03-14)
are regularly eliminated during in vivo tumor growth whereas the other 22 markers D3S1611, ACM, D3S1260, Wl-692, D3S2343, D3S966, D3S1029, D3S643 Wl-2420, MST1, GNAI2, D3S1235, D3S1298, GLB1, Wl-4193, D3S3658, D3S3559, D3S3678, Wl-6400, Wl-7947, B362WB9 and D3S...
Understanding inflammatory mechanisms in rheumatic diseases
(2014-11-05)
Rheumatoid arthritis (RA), Psoriasis (Ps) and Psoriasis arthritis (PsA) are chronic inflammatory autoimmune disorders, where primary targets are peripheral joints, skin and skin/joints respectively. Both innate and adaptive ...
Modulation of HIV immune responses in natural infection and after genetic immunization
(1999-09-14)
Identification and treatment of HIV-1 infection are both urgent, in view of the continued spread of the infection. We developed easy and inexpensive serological methods for the diagnosis and follow-up of children born to HIV-1-infected mothers. A...
Energy expenditure and accelerometer cut-points for sedentary behavior and physical activity in spinal cord injury : implication for guiding and prevention
(2019-09-13)
·kg-1 ·min-1 and the variable that best explained the variance for energy expenditure during rest (24 hours) was bodyweight r 2= 0.37 for the total cohort. During non-exercise activities (wheeling indoors/outdoors Borg RPE 10-11 and setting table...
Genetic studies in familial non-BRCA breast cancer
(2017-11-09)
Family history is an important risk factor for breast cancer, the presence of breast cancer in a first degree relative in general nearly doubles the risk and the risk increases with the number of affected relatives. Pathogenic mutations in BRCA1...
Functional characterization of cytosolic and mitochondrial thioredoxin reductases
(2006-09-15)
a link between selenium and vitamin E in the protection against lipid membrane peroxidation. Here, we present evidence that TrxR1 is a major reducer of ubiquinone, a regenerator of vitamin E. This reduction is entirely selenium dependent, and puts...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Estimation of gestational age by ultrasound and extreme prematurity
(2012-05-16)
Accurate estimation of the gestational age of the fetus is a key assessment made by providers of obstetric care during pregnancy, since decisions concerning management strategies are dependent on this estimate. Thus, the ...
Characterisation of CD8 T cells in mucosa associated lymphoid tissue : implications for immune control of HIV-1 infection
(2006-02-24)
The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. A primary focus of this thesis...
Oxidoreductases and RNA degradosome controlling virulence-associated traits of Salmonella enterica serovar Typhimurium
(2013-09-04)
tolerance and in virulence of S. Typhimurium. We demonstrated that ScsABCD proteins are dispensable for invasion in cultured epithelial cells under normal invasive conditions, although ScsABCD acts as a suppressor of SPI-1 mediated invasion upon oxidative...