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Clinical fluorescence cytometry : improvements to preparation methods and instrumentation
(1999-05-21)
Fluorescence cytometry, which can be carried out by flow or image cytometry (FCM, ICM), provides a highly sensitive and specific tool for quantitative analysis of cell material. It is emerging from being a pure research ...
Magnetic resonance imaging for the assessment of liver function
(2011-06-10)
This thesis presents dynamic hepatocyte-specific contrast-enhanced magnetic resonance imaging (DHCE-MRI) as a new method for total and segmental liver function assessment. The method is based on the hepatocyte-specific ...
Regulation of gene expression by non-protein-coding RNAs
(2009-01-29)
The human genome sequencing projects revealed that the human genome contains over 3 billion DNA base pairs, but only 20,000 25,000 protein-coding genes. In fact, only about 1.2% of the genome codes for proteins. Surprisingly, ...
Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility
(2008-09-26)
lipoprotein receptor-related protein (LRP)/CD91. Interaction of TSP-1 with its cell surface receptors calreticulin (CRT), LRP and integrin associated protein (IAP)/CD47 was promoting motility of T cells in 3D collagen through CD47. T cell surface TSP-1 also...
Stress, satisfaction, and quality : studies of organizational and individual well-being in health
(2013-02-18)
The aim of this thesis is to indicate key organizational attributes in the health care work environment that can have an impact on both personnel well-being and the quality of care they provide. In order to achieve this ...
Molecular signatures of early life exposures and complex diseases : applications using epigenetics and transcriptomics data
(2022-10-24)
Environmental exposures and early life stressors may influence developmental processes and have long-term health consequences, potentially mediated by molecular mechanisms such as epigenetic modifications. The most extensively ...
A clinical epidemiological study on end-stage liver disease in Ghana
(2022-06-01)
End-stage liver disease (ESLD), including advanced liver cirrhosis and hepatocellular carcinoma (HCC), is the final stage of long-standing injury to the liver due to risk factors such as chronic viral hepatitis and alcoholic ...
Shoulder and upper extremity impairments, activity limitation and physiotherapeutic exercise in women with rheumatoid arthritis : a biopsychosocial approach
(2000-05-04)
The aim of this thesis was to evaluate both specially-designed and commonly used instruments for measuring impairments, activity limitation and health-related quality of life (overall Sickness Impact Profile (SIP)). The ...
Genetic determinants for susceptibility, progression and prognosis of prostate cancer
(2015-10-23)
Prostate cancer is the most commonly diagnosed form of non-skin cancer among men in developed countries. Although a large proportion of patients eventually die from the disease, many indolent tumors are found via prostate ...
Misoprostol as a family planning drug : use in pregnant and non-pregnant women
(2014-10-28)
Background: Availability of comprehensive family planning services is fundamental in improving and ensuring women’s right to life and health. An estimated 222 million women have an unmet need for contraception, and 43.8 ...