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Immunogenetics and treatment of experimental autoimmune encephalomyelitis
(1999-05-28)
haplotypes the region between MOG 91-114 contained the main encephalitogenic determinants. Beside a T cell determinant MOG 91-108 also contains a linear B cell determinant, suggesting a role for B cell mediated immunity in encephalitogenicity. Binding...
Mitochondrial function adaptations to changed metabolic conditions
(2010-09-09)
for obesity. Six months after the gastric bypass surgery, the subjects had lost on average 25.5 kg of their body weight. Coupled, ADP generating respiration, had increased significantly (+69%, P≤0.01), while the uncoupled respiration was not significantly...
Dust mite allergens : cloning, characterisation and T-cell responses
(2001-03-09)
The number of allergens that have been cloned has increased dramatically
during the last 10 years, and today, over 400 allergen sequences are
available in the databases. In addition, at least 15 dust mite allergens
have ...
Molecular organization and in situ assembly of the human skin barrier
(2016-10-07)
A deficient skin barrier function is a characteristic feature of skin diseases such as eczema, psoriasis and the ichtyoses. A malformation of the lipid matrix might be a major factor in barrier deficient skin disease. To ...
Ecological impact of antibiotic treatment on human normal microflora
(2013-05-20)
-spectrum cephalosporin active against methicillin-resistant Staphylococcus aureus. Twelve healthy volunteers received ceftobiprole. Plasma and fecal samples were collected according to the study design for analysis. Plasma concentrations of ceftobiprole were 14.7-24.5 mg...
Impact of pneumococcal conjugate vaccine on pneumococcal disease, carriage and serotype distribution : comparative studies in Sweden and Uganda
(2016-04-01)
invasive pneumococcal disease (IPD) there. Current PCVs include 10 or 13 of the more than 97 known pneumococcal serotypes. In Stockholm County, Sweden, PCV7 was introduced for infants born from July 2007, at 3, 5, and 12 months of age and in 2010...
Stress, satisfaction, and quality : studies of organizational and individual well-being in health
(2013-02-18)
The aim of this thesis is to indicate key organizational attributes in the health care work environment that can have an impact on both personnel well-being and the quality of care they provide. In order to achieve this ...
On gender dysphoria
(2017-03-10)
Gender identity refers to an innate and deeply felt psychological identification as a female, male, or some other non-binary gender. Gender identity may be congruent or incongruent with the sex assigned at birth. Gender ...
Vascular related pathologies in cardiovascular disease and cancer
(2017-04-28)
Cardiovascular disease (CVD) and cancer are the leading causes of death worldwide. A damaged endothelium is one of the factors contributing towards these diseases. This thesis focused on understanding the implications of ...
Pharmacological targeting of mutant p53 family members
(2011-04-18)
accumulation of mutant p53. In addition, PRIMA-1(MET) induced the levels of heat shock protein (Hsp) 70 and a redistribution of the PML nuclear body-associated proteins CBP, PML, Hsp70, and the Epstein-Barr virus encoded protein EBNA-5 to nucleoli. Our results...