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Studies of the vascular endothelial growth factors, VEGFs, and their receptors, focusing on VEGF-B
(1999-05-19)
kinases are known, including three receptors for vascular endothelial growth factors (VEGFs) and a receptor for angiopoietins, Tie-2, as well as the related orphan receptor Tie-1. Vascular endothelial growth factor (VEGF) is a prime regulator...
Molecular and epidemiological studies of bladder exstrophy and epispadias complex
(2023-04-13)
to female ratio is almost equal. It is regarded to result from a disruption during the normal embryogenesis of the urinary bladder. The recurrence risk of bladder exstrophy is around 1 in 70 siblings. Several reports on chromosome aberrations and twin...
Oxidative stress and age-related cataract
(2015-09-04)
Age-related cataract is a clouding of the lens that leads to decreased vision. It increases with age and is one of the leading causes of blindness worldwide. The only treatment currently available is surgery. Therefore, ...
A multifactorial approach to targeting signalling pathways in diabetic foot ulcers
(2019-10-18)
, angiogenesis, differentiation and apoptosis. In paper-I, we show that Notch1 is activated in human and rodent skin and several processes central to wound healing are impaired in response to hyperglycemia in a Notch1 dependent manner. Mechanistically, we show...
Long-term exposure to air pollution from road traffic and development of airway and allergic diseases in children
(2012-11-22)
of <10 μm (PM10) from traffic, were assigned to residential, day care, and school addresses by dispersion models. Air pollution exposure during the first year of life was related to an increased risk of sensitization to pollen allergens at 4 years (OR, 1...
Endometrial receptivity and regeneration in health and disease : molecular, cellular and clinical perspectives
(2022-02-25)
Each month, the endometrium regenerates under the influence of the ovarian hormones and builds up to a receptive state in preparation for embryo implantation. In the absence of pregnancy, it sheds during menses and the ...
Novel approaches for cancer immunotherapy
(2008-05-22)
Cancer immunotherapy, i.e. activation of the patient s own immune system to combat cancer, represents a treatment strategy which is being clinically tested to complement surgery, radiotherapy and chemotherapy the current ...
Mood disorders and consequences of pharmacological treatment
(2015-11-05)
Mental health issues are medical problems getting increased attention
throughout the world, and depression, only one among several types of
mental illnesses, are currently reported as the second leading cause of
disability ...
Apoptotic cell death in neural stem cells exposed to toxic stimuli
(2007-09-14)
, or to agents inducing oxidative stress such as 2,3-dimethoxy-1,4-naphthoquinone. Exposed cells exhibit apoptotic nuclear morphology, phosphatidylserine translocation to the outer leaf of the plasma membrane, cytochrome c release, caspase activation and DNA...
Experimental spinal cord injury : methodological and neuroimmunological contributions with some historical background
(2011-01-19)
type controls, behavioral recovery and axonal regeneration were evaluated after spinal cord overhemisection. In another set of KO mice (STAT4, STAT6, IFNγ, IFNγR and IRF1) and their corresponding wild type controls inflammatory and glial cell reactions...