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Studies on production and function of pulmonary nitric oxide
(1999-05-14)
Nitric oxide is involved in pulmonary vascular and bronchial regulation
and appears to be of paramount importance in the adaptation of the
pulmonary circulation at birth. Nitric oxide is present in exhaled gas.
The main ...
Regulatory networks of c-di-GMP signalling involved in biofilm formation, motility and host pathogen interactions in Salmonella typhimurium
(2013-08-09)
Adaptation to altered environmental conditions is one of the fundamental bacterial characteristics. The ubiquitous second messenger c-di-GMP plays a key role to adopt bacterial behaviour. Transition from motility to sessility ...
Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice
(2016-08-10)
Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and ...
The post-polio syndrome : studies of immunology and immunomodulatory intervention
(2005-09-02)
Late effects in patients with prior poliomyelitis were first reported in the nineteenth century and have been referred to as the post-polio syndrome (PPS). PPS is characterized by new muscular deterioration, fatigue and ...
Pituitary dysfunction and relation to cognitive and global outcome after traumatic brain injury or aneurysmal subarachnoid haemorrhage
(2018-09-19)
, were seen in 17% of patients with TBI and 12% with aSAH at 6 months and in 14% of patients with TBI and 3% with aSAH at 12 months. In total, 7 out of 91 patients required hormonal replacement (4 testosterone, 1 growth hormone, 2 hydrocortisone...
Cat allergy : diagnosis and characterization of important allergens
(2008-05-09)
Allergy affects about 25% of the population. Allergic diseases are
manifested in many ways, from mild rhinitis to life-threatening
anaphylaxis. Globally, more than 15% of children and adults are allergic
to pets.
The ...
Understanding inflammatory mechanisms in rheumatic diseases
(2014-11-05)
Rheumatoid arthritis (RA), Psoriasis (Ps) and Psoriasis arthritis (PsA) are chronic inflammatory autoimmune disorders, where primary targets are peripheral joints, skin and skin/joints respectively. Both innate and adaptive ...
Outcome after liver resection : epidemiological and clinical studies with special focus on the role of post-hepatectomy liver failure
(2018-05-24)
Background: Liver surgery has undergone significant developments over the last three decades. However, population-based data are scarce, and there is limited knowledge of the impact on mortality and possible treatment ...
Endometrial receptivity and regeneration in health and disease : molecular, cellular and clinical perspectives
(2022-02-25)
Each month, the endometrium regenerates under the influence of the ovarian hormones and builds up to a receptive state in preparation for embryo implantation. In the absence of pregnancy, it sheds during menses and the ...
Regulation of gene expression by non-protein-coding RNAs
(2009-01-29)
The human genome sequencing projects revealed that the human genome contains over 3 billion DNA base pairs, but only 20,000 25,000 protein-coding genes. In fact, only about 1.2% of the genome codes for proteins. Surprisingly, the number of human...