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The amygdala, experimental anxiety and alcohol consumption : an integrative study in the rat
(1999-05-14)
decreased in the lesioned. animals. Thus, our results support a relation between experimental anxiety and voluntary ethanol consumption in genetically heterogenous animals (paper 2). Ethanol dependence is a heterogenous disorder, with different relationships...
Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis
(2010-12-20)
oxidative stress by transcriptional activation of the catalytic subunit of NADPH oxidise, NOX2. Stable or conditional expression of EBNA1 was associated with the accumulation of telomere abnormalities, including loss and gain of telomere signals, telomere...
Understanding inflammation requires neuroscience
(2022-03-01)
Inflammation and its resolution are processes subject to neural regulation (1). The best-characterized immune-regulating reflex is the “inflammatory reflex”, in which the efferent branch of the vagus nerve plays a central ...
Studies on anti-inflammatory and vasoactive effects of mPGES-1 inhibition
(2022-12-13)
Inflammation is the basis for various serious illnesses such as rheumatic diseases, cardiovascular diseases, and cancer. Prostaglandin E2 (PGE2) is a pro-inflammatory lipid mediator produced by cyclooxygenases (COX1/2) and the microsomal...
Effects of chemotherapy on bone growth and chondrocyte cell death signaling
(2010-11-01)
. Therefore, we hypothesized that Bax, a pro-apoptotic member of the Bcl-2 family that is known to regulate intrinsic apoptosis, may play a key role in dexamethasone-induced retardation of bone growth. In chondrocytes, dexamethasone induced conformational...
Cardiovascular aspects in mild primary hyperparathyroidism and the outcome after parathyroidectomy
(2011-05-05)
Data on the extent and clinical significance of cardiovascular abnormalities in primary hyperparathyroidism (PHPT) are conflicting. The main objective of this thesis was to evaluate the cardiovascular function in patients ...
Intrauterine immunology in allergy and infection
(2009-01-02)
investigated different factors in the placenta in relation to chorioamnionitis. In the first study, we investigated TLR2 expression. We demonstrated that expression of TLR2 was lower in placentas with chorioamnionitis compared to healthy placentas...
Studies on novel interactors in human adipose tissue
(2011-05-19)
Obesity is associated with a mild inflammation and altered protein secretion in adipose tissue. These changes have been suggested to contribute to the development of obesity-associated disorders including, insulin resistance, dyslipidemia, type 2...
The effect of alpha-HGA on HIV-1 replication
(2009-03-13)
the mechanism of [14C]alphaHGA uptake by human T cell line. Uptake of [14C]alphaHGA into H9 cells was time- and dose- dependent. The uptake properties showed low temperature dependency (Q10<2) and the cellular uptake of [14C] labeled alphaHGA was not inhibited...
Energy expenditure and accelerometer cut-points for sedentary behavior and physical activity in spinal cord injury : implication for guiding and prevention
(2019-09-13)
(VO2peak), peak heart rate (HRpeak) and Borg rating of perceived exertion (RPE) were used for categorizing standardized activities into different levels of intensity. In study IV dominant-wrist-worn accelerometer (ActiGraph GT3X+) cutpoints were...