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Candidate genes and chromosomal loci in multiple sclerosis
(1999-03-30)
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with a putatively autoimmune etiology. The pathophysiological basis of MS is incompletely known, although both genetic and environmental ...
Investigating the role of p73 proteins in controlling the tumor microenvironment
(2020-10-20)
Cancer is a multifactorial disease governed by oncogenes and tumor suppressors that not only impact on the behavior of the cancer cells but also influence many processes in the surrounding tumor microenvironment. The most ...
Extremely preterm birth : brain imaging and outcome at early school-age
(2018-05-09)
There has been a dramatic increase in the survival of extremely preterm children over the last decades, and the awareness of the consequences of extremely preterm birth on the developing brain is increasing. This thesis ...
The role of X-ray imaging and musculoskeletal ultrasound in the diagnosis and management of rheumatoid arthritis
(2014-10-31)
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease characterized by symmetric joint inflammation that often involves the small joints of the hands and feet, with progressive destruction, deformity, and ...
Cardiovascular disease in dementia
(2016-12-08)
The objective of this thesis was to characterize the burden of cardiovascular diseases in patients with dementia, their treatment and association with survival. Further, we aimed to explore whether cardiac structure in ...
Epidemiological studies on type 2 diabetes : assessment of diabetes risk factors and study participation
(2012-02-02)
Type 2 diabetes is a disease with increasing prevalence. Better knowledge of risk factors may form the bases for specific interventions and preventive measures. The aim of this thesis was to contribute to the knowledge on ...
Rheumatoid arthritis : pharmacological modulation of cytokines : aspects of clinical response and endocrine regulation
(2006-01-06)
Rheumatoid arthritis (RA) is a systemic inflammatory disease primarily affecting the joints. In the pathogenesis several cells of the immune systeme and messengers of the immune systeme, cytokines, are important. In this ...
Distal radius fractures : epidemiology and aspects of surgical management
(2020-11-06)
Distal radius fractures (DRFs) are the most common fractures treated by physicians. About 20% of all DRFs are treated surgically. The main surgical methods are volar plate fixation, external fixation and percutaneous ...
CYP2D6-polymorphism and effect of adjuvant tamoxifen in breast cancer patients
(2023-09-04)
. Although the clinical relevance of the proposed target level of endoxifen at around 5.9 ng/mL needs to be evaluated, it is concerning that a third of our study patients had endoxifen concentrations below this level with tamoxifen at the current standard...
Investigation of T cell driven arthritis induced by mannan in ZAP70 mutated SKG mice
(2016-08-10)
Autoimmune diseases are particularly challenging to study in human due to their complex multifactorial nature. In rheumatoid arthritis (RA), self-reactivity directed against joints leads to pain, tissue destruction and ...