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Cell biological mechanisms and activity markers of eosinophils in relation to allergic inflammation
(1999-04-29)
It is becoming increasingly apparent that the pathogenesis of respiratory allergic diseases, including asthma and allergic rhinitis, is closely linked to the presence of chronic inflammation. One of the leading actresses ...
Chronic bone marrow failure and transfusion patterns : epidemiological studies of blood transfusions and outcomes in patients with myelodysplastic syndromes
(2020-12-22)
Myelodysplastic syndromes (MDS) encompass a diverse group of clonal hematological malignancies characterized by dysplasia and ineffective hematopoiesis with an increased risk of leukemic evolution. It is a disease of the ...
Mechanisms controlling midbrain dopaminergic neuron development
(2016-11-25)
. This phenotype and the morphogenesis defect found in Wnt5a−/− mice were worsened in Wnt1−/−; Wnt5a−/− mice, indicating the existence of a previously unsuspected cooperation between Wnt1 and Wnt5a in mDA neuron development in vivo. Based on these results, we...
Nitric oxide in exhaled gas : studies on physiological regulation and measurements in infants and children
(1999-09-16)
Nitric oxide (NO) is found in the exhaled gas of humans, starting from birth, and is increased in adult patients with bronchial asthma. This study assessed whether the measurement of NO in exhaled gas is technically feasible ...
Studies on novel interactors in human adipose tissue
(2011-05-19)
Obesity is associated with a mild inflammation and altered protein secretion in adipose tissue. These changes have been suggested to contribute to the development of obesity-associated disorders including, insulin resistance, ...
New light on neurocognitive processes linked to autism and attention deficit and hyperactivity disorder in childhood : studies of eye movements in twins
(2020-05-08)
Visual attention and oculomotor response inhibition have been associated with Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) respectively. The aim of this thesis was to increase our ...
Delivery of DNA vaccines against cancer
(2006-10-06)
DNA vaccines against cancer have shown promising results in animal models. Efficient antigenspecific T cell responses and tumor protection have been demonstrated after vaccination with DNA encoding tumor antigens in mice. ...
Neutrophil interactions with Streptococcus pyogenes and Staphylococcus aureus
(2017-04-03)
Streptococcus pyogenes and Staphylococcus aureus are Gram-positive bacteria that share many features, including clinical presentations and pathogenic mechanisms, and yet, they still have unique properties. They both cause ...
Social influences on affective responses to negative experiences
(2023-01-25)
As social human beings, the way we emotionally respond to what happens around us is often regulated by our interactions with others. The overall aim of this thesis is to advance the understanding of how social influences ...
Clinical studies of hemophagocytic lymphohistiocytosis
(2011-11-07)
years, overall 5-year probability of survival in the HLH-94 treatment study was 55%, and 5-year survival post-transplant was 67%. Altogether, 73% of the patients received transplants or achieved long-term remission without HSCT. There was no significant...