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Constipation : symptoms and findings in relation to structural and functional abnormalities
(1999-02-19)
The aim of this study was to increase the knowledge about functional constipation with special reference to symptoms analysis, laboratory investigations and histopathology findings. 155 consecutive patients with intractable ...
Immunogenetics and treatment of experimental autoimmune encephalomyelitis
(1999-05-28)
haplotypes the region between MOG 91-114 contained the main encephalitogenic determinants. Beside a T cell determinant MOG 91-108 also contains a linear B cell determinant, suggesting a role for B cell mediated immunity in encephalitogenicity. Binding...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Statistical methods for the detection, analyses and integration of biomarkers in the human genome and transcriptome
(2014-09-09)
Most human diseases have been shown to have a genetic basis that is linked to regulation of gene expression at the transcriptional or post-transcriptional level. In the central dogma of biology, deoxyribonucleic acid (DNA) ...
Role of IL-7 in immune activation during HIV-1 infection
(2011-08-02)
Viral replication, lymphopenia and microbial translocation at the mucosal surfaces lead to a chronic state of immune activation during HIV-1 infection. Chronic immune activation is believed to impact on the functionality ...
Pituitary regulation of plasma lipoprotein metabolism and intestinal cholesterol absorption
(2005-11-18)
Increased levels of plasma cholesterol are associated with a higher risk to develop atherosclerosis, the leading cause of death in Western societies. The major part of cholesterol in human blood is transported within ...
Avidity-guided radionuclide therapy for thyroid cancer
(2022-09-01)
of tumour cells that express thyroglobulin (correlation coefficient r = 0.50) and the tumoural Ki-67 index (r = -0.49). Avidity was found to be seven-fold higher in favourable histological subtypes of PTC. High patient age was also found significantly...
Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells
(2008-10-24)
and brain fitted a two-compartmentmodel in both adult and pups. Pharmacokinetics was age-dependent with a terminal elimination half-life of 7h in brain and plasma in pups compared to <0.5 h in adult rats. Brain exposure to roscovitine expressed as AUC brain...
High-sensitivity cardiac troponin T in the emergency department : admissions, resource utilization and outcomes
(2017-05-18)
Background: Patients presenting with chest pain in the emergency department (ED) may have myocardial infarction (MI) requiring immediate treatment. High-sensitivity cardiac troponin T (hs-cTnT) was recently introduced as ...
Biomarkers and psychological stress in amyotrophic lateral sclerosis
(2023-04-05)
Amyotrophic lateral sclerosis (ALS) is a complex and progressive neurological disorder that causes a wide range of symptoms, including muscle weakness, mobility impairment, and marked functional decline. Unfortunately, ...