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Surgical trauma, inflammation and tissue injury
(1999-01-29)
Surgical tissue trauma is a strong stimulus for local inflammation, including leukocyte recruitment. While such a response may be of importance for the defense against microorganisms, it is also clear that inflammation may ...
Early cardiovascular risk markers and cardiac function in children with chronic kidney disease
(2016-04-08)
, present in 7.1% of CKD and 12.5% of CKD-T patients (Paper III). Furthermore, TDI was more sensitive in diagnosing subtle changes in cardiac function compared to conventional pulse wave Doppler (PWD). The most important risk factors for subclinical CVD were...
Biopsies, diagnosis and prognosis in prostate cancer
(2011-11-01)
Prostate cancer is the third most common cancer in men worldwide, and poses a challenge both for patients and health care systems. Many aspects of prostate cancer are controversial, from screening for early detection to ...
Endothelial dysfunction in atherosclerosis and type 2 diabetes : clinical and molecular studies of the role of endothelin and arginase
(2018-05-08)
Background: Atherosclerosis is a modern world scourge and the number of people worldwide diagnosed with type 2 diabetes (T2D) is on the rise, causing much morbidity and mortality. Endothelial dysfunction (ED) is an early ...
Multiple circuits controlling the versatility of locomotion : molecular and connectivity principles in zebrafish
(2022-11-24)
Locomotion is produced by neuronal circuits in the spinal cord. These motor circuits rely on the activation of supraspinal centres and transform descending excitatory drive into coordinated rhythmic activity. Far from ...
Effect of cycline-dependent kinase and matrix metalloproteinase inhibitors on hematopoietic and leukemic cells
(2008-10-24)
and brain fitted a two-compartmentmodel in both adult and pups. Pharmacokinetics was age-dependent with a terminal elimination half-life of 7h in brain and plasma in pups compared to <0.5 h in adult rats. Brain exposure to roscovitine expressed as AUC brain...
Experiences, expectations and treatment decision-making in men with metastatic prostate cancer
(2022-11-01)
and study III had a qualitative, serial design. In study I, two matched groups of men with mPC (n=106) and non-mPC (n=211) were followed over 5 years with repeated questionnaires. Quality of life, symptoms and functioning were compared between the groups...
The burden of back pain : evaluation of costs and health outcomes
(2020-11-27)
Background: Back pain is a leading cause of disability in the world. Beyond the negative impact on people’s health and quality of life, back pain is associated with substantial costs both within and outside the health care ...
Persistent inflammatory pathways in rheumatoid arthritis despite anti-rheumatic treatment
(2010-11-18)
affects 0.5-1% of the population, is associated with important co-morbidities and represents a heavy economical burden. New strategies, employing early and aggressive therapies with classical drugs or new agents, have resulted in impressive improvements...
Mechanistic insights into the biosynthesis of polyketide antibiotics
(2006-11-24)
Anthracyclines are a group of aromatic polyketide compounds with significant medical importance due to their antineoplastic properties. Doxorubicin and daunorubicin members of this family are among the two most commonly ...