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Effects of anti-neoplastic therapy on tooth and bone formation : clinical and experimental studies
(1998-11-13)
Long-term dental sequelae after treatment of childhood malignancies were studied in patients treated with chemotherapy and with bone marrow transplantation (BMT) before 12 years of age. Compared to healthy controls, there ...
Uveal melanoma : epidemiological and clinical aspects
(2005-09-23)
diagnosed with uveal melanoma. The age-standardized incidence rate of uveal melanoma declined significantly among men from 11.7 cases/million to 8.4 cases/million (p=0.002) and was stable in females, 10.3 cases/million to 8.7 cases/million (p=0...
Development of multi-cellular human lung models to study inflammatory mechanisms and cell-cell interactions
(2018-05-17)
It is well known that exposure to toxicants in the environment is associated with a wide range of health effects. The airway epithelium which forms the first line of defense, plays critical roles in the defence against ...
Prevention of growth failure caused by glucocorticoid treatment
(2023-03-10)
Children with chronic inflammation often suffer from growth failure and many of these children are treated with high doses of glucocorticoids (GCs). However, the underlying mechanisms of growth failure under conditions of ...
Clinical studies of glucose variability and hypoglycemia in adult patients with type 1 diabetes
(2011-11-02)
from 70 measurements over a period of 4 weeks. The onset and progression of micro- and macrovascular complications were recorded from 1990 to 2001. HbA1c values were recorded from 1985 to 2001. HbA1c variability was measured as the SD of collected HbA1c...
Regulatory function of homeobox genes in the development of C. elegans
(2010-09-10)
by ceh-37/ttx-1. We mapped the promoter regions of ceh-26 and of the target gene clh-4 to identify putative homeodomain proteins binding sites. Given that these homeobox genes are well conserved in evolution, we may expect that parts of this cascade...
Prenatal metabolic risks for offspring neurodevelopmental and psychiatric disorders
(2021-09-24)
found that preterm birth (moderately preterm: HR=1.43, 95% CI, 1.38–1.47; very preterm: HR=2.86, 95% CI, 2.67–3.07; and extremely preterm: HR=5.40, 95% CI, 4.95–5.89) and abnormal birth size (small for gestational age [SGA]: HR=1.53, 95% CI, 1...
Glomerulopathy in normoalbuminuric adolescents with type 1 diabetes : relations between structure, function, metabolic control and ambulatory blood pressure
(2005-04-29)
An increase in the incidence of type 1 diabetes in childhood has been
reported in several countries, especially among the youngest children.
Although clinically apparent diabetic vascular disease is rare in
children and ...
Molecular and clinical studies of intestinal malrotation
(2022-04-13)
, even though six needed re-do surgery because of recurrence. In study II, 138 children were included based on strict inclusion criteria, 1-15 years old. 125 (91%) had Ladd’s procedure and only one had recurrence needing re-do surgery. The major findings...
Mechanisms of chronic complications of diabetes with focus on mitochondria and oxygen sensing
(2009-12-25)
Chronic complications of diabetes represent a major medical and economical concern. It is an imperative need to establish the pathogenic mechanisms that contribute to development of chronic complications in order to design ...