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Studies on the cytokine network in multiple sclerosis
(1998-11-06)
Multiple sclerosis (MS) is considered to be an inflammatory immune-mediated disease of the central nervous system (CNS), the aetiology of which remains enigmatic. Cytokines produced by infiltrating inflammatory cells and ...
Novel skeletal stem and progenitor cells and their regulation
(2022-01-20)
The development of bone and cartilage, which provide the framework of the skeletal system,
is complex. In this context stem and progenitor cells play a crucial role by producing
differentiated cells. Hormones are important ...
Sex and gender aspects on intensive care : access, intensity and outcome
(2021-05-06)
with 8,598 adult patients admitted between 2006 and 2016 to the ICU at Karolinska University Hospital in Stockholm, Sweden. This study explored differences in the efferent arm, i.e., sex- and gender-based differences in discharge from the ICU...
Cisplatin-induced tumor cell death signaling and potentiation by energy metabolism inhibitors
(2007-01-05)
Treatment of cancer is associated with challenges including the tumor development of resistance. By elucidating intracellular signal transduction pathways elicited by therapy it is possible to identify structures and ...
Customization of tamoxifen therapy : not only a dream
(2011-09-06)
Breast cancer (BC) is the most common form of cancer in western women. The grand majority of the afflicted women are eligible for endocrine treatment. Tamoxifen has been the golden standard treatment for more than three ...
E-epidemiology : adapting epidemiological methods for the 21st century
(2009-08-28)
The traditional methods in epidemiological data collection are both costly and time consuming and less convenient for longitudinal large-scale studies. During the last decades, epidemiological studies suffer from low ...
Energy expenditure and substrate utilization during critical illness
(2020-09-25)
Background: Critical illness leads to major alterations in metabolism. The net result is a state where catabolism predominates over anabolism. The associated loss of lean body mass is significant and potentially harmful. ...
The role of SOXC transcription factors in B-cell development and lymphoid malignancies
(2017-09-15)
Mantle cell lymphoma (MCL) accounts for 5-10% out of all Non-Hodgkin lymphomas (NHLs) and is one of the most aggressive forms of lymphomas with a median survival of less than 5 years. Currently, MCL is considered to be an ...
Wnt/beta-catenin signaling in midbrain dopaminergic neurons
(2006-04-07)
Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at ...
Fate selection in the neural crest lineage and its regulation
(2023-08-16)
The neural crest is a transient embryonic progenitor cell population that generates a diverse
array of cell and tissue types, including cartilage, bone, teeth, soft connective and adipose
tissues, peripheral sensory and ...