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Melatonin secretion and excretion : a clinical study focusing on factors and disease states which might influence melatonin
(1998-10-23)
The overall aim of this thesis was to find out whether other factors than the the light-dark changes influence the function of the pineal gland. Since melatonin (MT) itself, or its precursor serotonin, are of importance ...
Insulin-like growth factor 1 receptor, novel functions and future possibilities
(2017-09-01)
Insulin like growth factor-1 receptor (IGF-1R) has been shown to be important for cancer cell growth and survival, and is often overexpressed in malignant and premalignant tissues. Ligand binding to IGF-1R induces transphosphorylation and activation...
Regulation of eukaryotic cell physiology using organic bioelectronics
(2011-03-25)
The field of organic bioelectronics deals with the implementation of conducting polymer science in biology and medicine. The purpose of this thesis was to develop organic bioelectronic devices for the regulation of eukaryotic ...
Diabetes and puberty : studies on hormonal factors of importance to the blood glucose control
(2000-11-24)
It is well known that, in children with type 1 diabetes, metabolic control often deteriorates during puberty. Better understanding of the mechanisms that cause deterioration of blood glucose control can lead to improved therapeutic approaches...
Consequences of outsourcing referrals for radiological examinations
(2016-11-14)
Background: Demands for ever more effective healthcare and care accessibility for all patients continue to increase the workload in diagnostic radiology departments. Along with rapid developments in imaging technology which ...
In vivo functions of mammalian glutaredoxin 2
(2008-08-29)
isoforms: (1) mitochondrial Grx2a corresponds to human Grx2a, (2) Grx2c is a cytosolic protein homologous to human Grx2c but derived from different transcript variants and (3) Grx2d, an enzymatically inactive protein that lacks structurally important amino...
Regulators of angiogenesis in diabetes and tumors
(2005-11-21)
and the potential risk of cellular oxidative damage. The master regulator of oxygen homeostasis is Hypoxia inducible factor-1 (HIF-1). Our basic hypothesis was therefore that HIF modulation might be relevant for diseases characterised by dysregulated angiogenesis...
Genetic studies in familial non-BRCA breast cancer
(2017-11-09)
Family history is an important risk factor for breast cancer, the presence of breast cancer in a first degree relative in general nearly doubles the risk and the risk increases with the number of affected relatives. Pathogenic mutations in BRCA1...
Gene environment-interaction and cardiovascular phenotype in obesity and diabetes
(2019-02-22)
) and endothelial dysfunction as well as a significant dysregulation of chromatin modifier enzymes methyltransferase SUV39H1, demethylase JMJD2C and acetyltransferase SRC-1 as compared to control VFA. These changes were associated with reduced methylation...
Improved statistical methodology for high-throughput omics data analysis
(2021-07-19)
Over the last two decades, the advent of high-throughput omics technology has substantially revolutionized biological and biomedical research. A large volume of omics data has been produced with the rapid development of ...