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Liver tumour promoting effects by polychlorinated biphenyls
(1998-11-13)
and foci occurrence for the selection of growth parameters in the model.
The tumour promoting potency of two PCB congeners, 2,3,4,5,3',4'-hexachlorobiphenyl (PCB156) and 2,4,5,3',4'-pentachlorobiphenyl (PCB118), was studied individually in a two...
Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle
(2001-05-18)
Cysteinyl-leukotrienes, i.e. leukotriene (LT) C4, D4 and E4, are inflammatory mediators and potent airway- and vasoconstrictors. Two different cysteinyl-leukotriene receptors have been cloned, CysLT, and CysLT2. The aim of this thesis was to explore...
Roles of Notch signalling in early embryonic development
(2011-11-24)
Metazoan embryonic development requires a complex interplay of morphological processes coordinated with self-renewal and differentiation to correctly specify and maintain body cell types in the correct location. Notch ...
The role of nitric oxide in the gastrointestinal tract
(2012-11-21)
Nitric oxide (NO) is an important second messenger involved in the regulation of a multitude of mechanisms in the body, such as neurotransmission, smooth muscle contractility, host defense and immune regulation. Inflammatory ...
Inorganic and organic nitrates as sources of nitric oxide
(2012-05-15)
Inorganic nitrate (NO3-) and nitrite (NO2-) have generally been considered stable inactive end products of nitric oxide (NO) or unwanted residues in the food chain. While several recent studies surprisingly demonstrate ...
Osteoporosis in elderly women in primary health care
(2007-10-19)
of calcium and 400 IU of vitamin D3. Bone mineral
density measurements: The bone mineral densities (BMD) of the hip and
lumbar spine (L1 L4) were determined using Hologic QDR 4500 equipment for
DXA. The peripheral measurements on the calcaneus were performed...
Apoptotic cell death in neural stem cells exposed to toxic stimuli
(2007-09-14)
, or to agents inducing oxidative stress such as 2,3-dimethoxy-1,4-naphthoquinone. Exposed cells exhibit apoptotic nuclear morphology, phosphatidylserine translocation to the outer leaf of the plasma membrane, cytochrome c release, caspase activation and DNA...