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Bilateral neurogenic mechanisms following acute unilateral inflammation
(1998-11-26)
and inflammation.
Unilateral injection of a pro-inflammatory substance (50µg of Freund's adjuvant, 50µl of 2% carrageenan, 50µg IL-1[alpha] or 50µl of 10-5 M of substance P) into a rat's knee induced a bilateral release of substance P (SP)-, neurokinin A (NKA...
Emergency department crowding and hospital patient flow : influential factors and evidence-Informed solutions
(2016-09-06)
predicting failure for the 4hr target were: PIAD> 2hrs (OR 15.80 [13.35-18.71]), consultation (OR 20.98 [14.10- 31.22]), TnI (OR 13.37 [6.30-28.37]), MRI (OR 31.68 [6.03-166.54]), or CT (OR 16.48 [10.07-26.98]). Study IV found that the Australian hospital...
Amino acid predictors of HIV-1 coreceptor use in different subtypes and their application to antiretroviral treatment
(2014-01-10)
this further, 24 treatment failure patients infected with subtype C in Botswana were in paper III compared with 26 treatment-naïve patients with regard to coreceptor use, which was determined using the coreceptor use prediction algorithm Geno2pheno with a...
Female autism phenotypes : sex/gender differences in functioning, camouflaging, and eating problems
(2023-05-02)
Background: Autism is a neurodevelopmental condition defined by challenges in social interaction and communication and presence of repetitive patterns in behavior, interests, and activities alongside sensory processing ...
Hormonal regulation of HES-1 in breast cancer cells
(2008-05-21)
that exogenous expression of HES-1 causes cell cycle arrest in the G1 phase of the cell cycle. We found the cell cycle factor E2F-1, critical for G1 to S-phase progression, to be regulated by HES-1, via a cis-element in the 5 regulatory region of the E2F-1 gene...
Investigations of body mass, gastrointestinal, and dietary factors influencing the emergence and maintenance of eating disorders
(2020-10-20)
Eating disorders are severe psychiatric illnesses, characterized by dysregulated eating and distorted attitudes toward weight and body shape, causing enormous suffering for patients and their families. Although great ...
Bone marrow mesenchymal stem and progenitor cells in myeloid malignancies
(2017-10-24)
, and matrix proteins. Dynamic BM niche cell analysis and gene expression assay revealed that the BM niche alterations correlated with AML burden. We next functionally determined the roles of BM MSCs marked by Ebf2 expression in AML progression. We demonstrated...
Multiple sclerosis : from genetic variants to biomarkers
(2019-09-06)
to identify biomarkers for MS treatment. We took a candidate gene approach in paper III and studied the treatment effects on soluble cytokine receptors and observed changes in plasma levels of sIL-7Rα, sIL-2Rα and sgp130. In paper IV we took a multiplex...
To catch a killer : on the mechanisms of interferon alpha induced apoptosis
(2005-01-28)
triggering event in the caspase cascade. Furthermore, we show involvement of the mitochondrial pathway as demonstrated by activation of the pro-apoptotic Bcl-2 family members Bak and Bax, mitochondrial inner membrane depolarization and release of cytochrome c...
Psychological distress and breast cancer : a bidirectional link
(2022-11-09)
was used to estimate the odds ratio of invasive disease-free survival (iDFS). A two-fold increase of somatic mutation burden in genes of the glucocorticoid pathway was associated with a 17% (95% CI: 2%-35%) elevated odds of reaching iDFS endpoints...