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Studies on laboratory diagnosis of fungal infection and antifungal susceptibility
(1998-09-25)
%). Positive non-culture assay was recorded in 3 of 5 IFI patients. Of the empirically treated patients 36% had >2 positive non-culture assays.
The second aim was to investigate animal susceptibility of fungi. Fluconazole resistance (MIC >32.0 mg...
Combined sulphonylurea and insulin treatment for type 2 diabetes mellitus : metabolic and electrophysiological studies
(2000-03-10)
Type 2 diabetes is a prevalent disorder characterized by elevated blood glucose levels and associated with increased morbidity from micro- and macrovascular complications. Lowering of blood glucose has been shown to reduce the incidence...
The role of nitric oxide in porcine models of asthma and acute lung injury
(2000-11-24)
with metyrapone (a cortisol-synthesis inhibitor) severely enhanced LPS-induced ALI and septic shock and was therefore included in the subsequent sepsis studies.
Inhalation of a low (0.2 p.p.m.) and a high (20 p.p.m.) dose of NO was shown to have protective...
Microenvironmental regulation of neural stem cell differentiation
(2014-11-21)
The central nervous system consists of complex networks of neurons and other specialized cells that process information from within and outside the organism to create an output. The development of this complex machinery ...
Tobacco smoking and vertical periodontal bone loss
(2005-05-18)
revealed a right - left hand side symmetry. Cigarette smoking was significantly associated with the prevalence and severity of vertical bone defects (Studies II and III). The relative risk associated with current smoking was 2 to 3-fold increased...
To cut or not to cut? Episiotomy in vacuum extraction
(2022-04-05)
significantly higher rate of intrapartum cesarean section among women ≥40 years, both after spontaneous onset of labor (adjusted odds ratio (aOR) 3.07, 95%CI 2.81-3.35) and induction of labor (aOR 2.51, 95%CI 2.24-2.81). The risk of VE was also increased...
Studies of genetic mosaicism in rare diseases
(2022-04-01)
Mosaicism in human genetics refers to an individual harboring two or more genetic compositions, all derived from the same fertilized egg. Common signs of genetic mosaicism are asymmetric growth, skin aberrations or vascular ...
Exploring the role of mesenchymal stromal cells in endometriosis
(2018-11-16)
have been suggested to exist as MSC1 (an immunostimulatory phenotype), or as MSC2 (an immunosuppressive phenotype), with the latter phenotype being the most commonly investigated in the literature (see Table 1). Therefore, herein it was hypothesized...
Cellular mechanisms of human muscle fatigue and disease-related loss of muscle function
(2020-08-27)
A loss of skeletal muscle function and mass is a hallmark of several diseases resulting in a dismal life quality and poor prognosis. Impaired intracellular Ca2+-handling has been proposed as an underlying cause of these manifestations. This thesis...
Endothelial dysfunction in atherosclerosis and type 2 diabetes : clinical and molecular studies of the role of endothelin and arginase
(2018-05-08)
Background: Atherosclerosis is a modern world scourge and the number of people worldwide diagnosed with type 2 diabetes (T2D) is on the rise, causing much morbidity and mortality. Endothelial dysfunction (ED) is an early sign of atherosclerosis...