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Neurotrophic signalling by GDNF and its receptors
(1998-05-12)
Many investigators have sought a polypeptide which would alleviate the neuronal loss associated with Parkinson's disease--specifically dopaminergic neurons of the ventral mesencephalon. The survival of this population of ...
Quantitative cataract measurement with the Scheimpflug technique
(1999-11-12)
Cataract is the most prevalent blinding eye disease. Scheimpflug photography is an objective method for documentation of lens nuclear opacity. Using the Scheimpflug slit-lamp technique, a photograph, in focus from the ...
Molecular regulation and analysis of neural stem and cancer cell characteristics
(2012-05-25)
available voltage sensitive dye (VSD), JPW3027, for accurate characterization of neurons differentiated from NSCs, regarding their ability to generate action potentials (AP). We found that extracellular application of this dye improves labeling of cellular...
Premenstrual disorders : risk factors, comorbidities and health impact
(2022-05-09)
Premenstrual disorders (PMDs) are characterized by affective and physical symptoms that cyclically occur 7-10 days before the menstruation and affect millions of women of reproductive age worldwide. Despite its commonness, ...
Extremely preterm birth : brain imaging and outcome at early school-age
(2018-05-09)
There has been a dramatic increase in the survival of extremely preterm children over the last decades, and the awareness of the consequences of extremely preterm birth on the developing brain is increasing. This thesis ...
The burden of back pain : evaluation of costs and health outcomes
(2020-11-27)
Background: Back pain is a leading cause of disability in the world. Beyond the negative impact on people’s health and quality of life, back pain is associated with substantial costs both within and outside the health care ...
Deciphering microglia plasticity in glioma
(2019-01-11)
Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can ...
Regulation of eukaryotic cell physiology using organic bioelectronics
(2011-03-25)
The field of organic bioelectronics deals with the implementation of conducting polymer science in biology and medicine. The purpose of this thesis was to develop organic bioelectronic devices for the regulation of eukaryotic ...
Epidermal stem cells in physiological tissue regeneration, wound healing and cancer
(2016-01-29)
The mammalian skin is a versatile organ that protects from external harm, regulates the body temperature, and provides the touch sensation. Its epithelium, the epidermis, forms several highly regenerative structures as the ...
Functional and bioinformatical studies of the TGFb superfamily : identification and characterization of ALK7
(2001-11-02)
The transforming growth factor beta (TGFbeta) superfamily of polypeptide
growth factors encompasses more than 30 diverse mammalian members. They
are involved in most cellular processes, ranging from cell proliferation
and ...