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Mechanisms of cell type-specific gene transcription : studies on the choline acetyltransferase gene
(1998-05-06)
Choline acetyltransferase (ChAT) is the enzyme synthesizing the neurotransmitter acetylcholine. Previous studies from our laboratory on the regulation of the cholinergic phenotype have suggested the presence of regulatory ...
Concepts in DNA immunization overcoming viral diversity and enhancing plasmid immunogenicity
(2004-05-07)
On April 23, 1984, the prominent scientist Robert Gallo held a historical press conference at the Department of Health and Human Services, Washington D.C., USA. He announced that his laboratory at the National Institutes ...
Impact of infertility and assisted reproductive technology on cancer risk
(2018-05-07)
Ovarian stimulation drugs, in particular those used in assisted reproductive technology (ART)
treatments for infertility, have been suspected to influence cancer risk. In addition, infertility
per se may be a risk factor ...
Being present in caring encounters : a relational perspective on autonomy for older persons in municipal home help services
(2013-08-30)
The care of the old in Sweden and worldwide is developing towards an “aging in place.” Older people in Sweden are expected to remain in their own homes supported by municipal home help services. This development has entailed ...
Basis for reclassification of nasopharyngeal carcinoma
(2012-03-22)
Nasopharyngeal carcinoma (NPC) shows broad differences in racial and geographical distribution, radiosensitivity, and a multifactorial etiology. This thesis aims to identify molecular biomarkers with potentially valuable ...
Understanding cellular and cytoskeletal dysregulation in immunodeficiency diseases
(2019-12-18)
and function of immune cells. In paper III, we examined the anti-tumor responses of NK cells and T cells in X-linked neutropenia, a primary immunodeficiency caused by activating mutations in the actin-regulatory protein WASp, with increased risk...
Determination of transcription factor binding specificities
(2015-11-19)
The term "genetic code" refers to the way in which the information encoded in nucleic acids
is converted into the amino-acid sequence of proteins. There is however also a second genetic
code, one that is used by the cells ...
An epidemiological study on nasopharyngeal carcinoma
(2021-10-25)
Nasopharyngeal carcinoma (NPC) is a malignancy known for its unique geographic and ethnic distribution characterized by particularly high incidence in southern China, Southeast Asia, and North and East Africa, but being ...
Gene environment-interaction and cardiovascular phenotype in obesity and diabetes
(2019-02-22)
Although a large body of evidence supports the notion that genes determine cardio-metabolic traits and outcomes, the non-genetic regulation of these events has recently gained increasing attention. Plastic chemical ...
The role and regulation of nitric oxide and oxidative stress in cardiometabolic disease : focus on preeclampsia
(2022-04-29)
Cardiovascular (CVD) and metabolic diseases account for significant morbidity and mortality. Over the last decades, despite significant research and clinical effort, their global prevalence is estimated to further increase. ...