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Immunopathogenesis of experimental Chagas' disease
(1998-04-29)
Chagas' disease is a serious, life-threatening disease caused by the protozoan parasite Trypanosoma cruzi in South and Central America. Neither vaccine candidate(s) nor efficient, nontoxic chemotherapeutical agents exist ...
Regulatory networks of c-di-GMP signalling involved in biofilm formation, motility and host pathogen interactions in Salmonella typhimurium
(2013-08-09)
by binding the master regulator of flagella regulon FlhD4C2. Upon binding to FlhD4C2, STM1697 suppresses the functionality of FlhD4C2 to affect expression of downstream genes. Bioinformatic analysis revealed that the EAL domain proteins STM1344, STM1697...
Epidemiological characterisation of Bordatella pertussis in Sweden, 1970-2004
(2007-01-26)
Worldwide, Bordetella pertussis causes some 50 million cases of pertussis, and an estimated 2-300,000 fatalities each year. In Sweden vaccination against pertussis was introduced in the 1950s using diphtheria-tetanus-whole-cell ...
Prospective cohort studies of disability pension and mortality in a Swedish county
(2007-09-04)
The overall aim of this thesis was to study risk factors for disability
pension, focusing on sociodemographic risk factors and sick-leave
diagnoses, and also to investigate the risk of mortality among disability
pension ...
Probing and pushing potential genetics, development and training of cognitive functions
(2012-05-15)
Capacities of cognitive functions increase considerably during childhood and adolescence. This development is of importance as poor development can predict lower performance on academic skills. Furthermore, severe impairment ...
Multiple sclerosis : from genetic variants to biomarkers
(2019-09-06)
Multiple sclerosis (MS) is a common chronic autoimmune and neurodegenerative disease of the central nervous system (CNS). MS is a debilitating disease that affects young adults, especially females. Why we develop MS? Is ...
Host responses to human neural cell therapy in spinal cord injury
(2013-09-24)
mononuclear cells (PBMCs) and up-regulated CD4+CD25+forkhead box P3+ T cells, identified as induced regulatory T cells. However, hESC-NPCs but not hfNPCs dose-dependently triggered allogeneic PBMC proliferation, which may be at least partly due to TGF...
A ‘3 step’ IRT strategy for evaluation of the use of sum scores in small studies with questionnaires using items with ordered response levels : ‘To make a lot out of nothing’, from the Swedish locution: ‘Att koka soppa på en spik’
(2014-10-29)
was supposed to have in mind, at the construction of the questionnaire: 1. All items cooperate; 2. All items work together towards a common dimension; 3. Non-coherent/irrelevant items, as well as non-coherent answer profiles can be identified; 4. The subjects...
Role of IL-7 in immune activation during HIV-1 infection
(2011-08-02)
Viral replication, lymphopenia and microbial translocation at the mucosal surfaces lead to a chronic state of immune activation during HIV-1 infection. Chronic immune activation is believed to impact on the functionality ...
Set for life? Socioeconomic conditions, occupational complexity, and later life health
(2018-02-22)
Life expectancy has increased in the western parts of the world and more people reach old age. Some groups of people have benefitted more of the increase in life expectancy and have better health than others. Because of ...