Search
Now showing items 1-10 of 26
On retinoid receptors, Nurr1 and related transcription factors in the CNS
(1998-04-29)
It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects ...
Prevention of growth failure caused by glucocorticoid treatment
(2023-03-10)
Children with chronic inflammation often suffer from growth failure and many of these children are treated with high doses of glucocorticoids (GCs). However, the underlying mechanisms of growth failure under conditions of ...
Defining the role of migratory dendritic cells in priming T cells to mycobacteria
(2022-05-16)
Dendritic cells (DCs) are professional antigen-presenting cells that bridge innate and adaptive immunity by priming T cells. DCs residing at body surfaces such as skin sense invading microbes and respond by internalizing ...
Functional and bioinformatical studies of the TGFb superfamily : identification and characterization of ALK7
(2001-11-02)
The transforming growth factor beta (TGFbeta) superfamily of polypeptide
growth factors encompasses more than 30 diverse mammalian members. They
are involved in most cellular processes, ranging from cell proliferation
and ...
Studies of genetic mosaicism in rare diseases
(2022-04-01)
Mosaicism in human genetics refers to an individual harboring two or more genetic compositions, all derived from the same fertilized egg. Common signs of genetic mosaicism are asymmetric growth, skin aberrations or vascular ...
Cellular mechanisms of human muscle fatigue and disease-related loss of muscle function
(2020-08-27)
A loss of skeletal muscle function and mass is a hallmark of several diseases resulting in a dismal life quality and poor prognosis. Impaired intracellular Ca2+-handling has been proposed as an underlying cause of these ...
Aspects of arterial wall healing : re-endothelialization, intimal hyperplasia and vascular remodeling
(2019-05-08)
for validation and identification of novel treatment targets. The utilization of transcriptomic data to identify new biological pathways in the arterial wall healing process can be exemplified with proprotein convertase subtilisin/kexin 6 (PCSK6). Previously, we...
Preparing midwives as a human resource for maternal health : pre-service education and scope of practice in Gujarat, India
(2014-09-08)
One key strategy to achieve reduction in maternal and neonatal mortality is to scale up the availability of
skilled birth attendants (SBAs). The staff nurses (i.e., registered nurse and midwives) are skilled birth
attendants ...
Physical function, physical activity and quality of life in systemic sclerosis
(2019-04-11)
Background and aims: Systemic sclerosis (SSc) is a multisystem rheumatic disease characterized by fibrosis, vasculopathy and immune system activation. There is a dearth of knowledge how different subphenotypes such as ...
Host responses to human neural cell therapy in spinal cord injury
(2013-09-24)
in 40 and 33%, respectively. Locomotor function was not significantly different between groups, indicating that neither transplantation nor rejection altered functional outcome during the 6-week long study. Host microglial activation at the SCI epicenter...