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Dietary heterocyclic amines and human cancer risk
(1998-03-12)
Heterocyclic amines formed in meat during cooking are multi-site animal carcinogens and form DNA adducts in human tissues, but their relevance to human carcinogenesis has yet to be determined. The aim of this thesis was ...
Assessment of psychological and social factors in the workplace : psychometric aspects
(2008-10-24)
Psychosocial aspects of work have received increasing attention, partly
because of their postulated importance for the workers health. Among the
techniques developed for measurement of the psychosocial work
environment, ...
Cost analysis and policy implications in psychiatric care
(2009-04-01)
in Sweden in 2001 (Study I) was estimated at MSEK 85 774 (M€ 9 426, €1= SEK9.1). Indirect costs were totally predominant and constituted about 80% of the total cost, i.e. production losses due to early retirement, sickness absence and premature death...
Pituitary dysfunction and relation to cognitive and global outcome after traumatic brain injury or aneurysmal subarachnoid haemorrhage
(2018-09-19)
, were seen in 17% of patients with TBI and 12% with aSAH at 6 months and in 14% of patients with TBI and 3% with aSAH at 12 months. In total, 7 out of 91 patients required hormonal replacement (4 testosterone, 1 growth hormone, 2 hydrocortisone...
Helicobacter pylori eradication treatment and the risk of gastric and oesophageal cancer
(2018-12-19)
Helicobacter pylori is a strong and well-established risk factor for gastric cancer, but seems to decrease the risk of oesophageal adenocarcinoma. Thus, eradication treatment for Helicobacter pylori may decrease the risk ...
CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions
(2010-11-24)
the influence of the genetic variant CYP2C9*3 on the CYP2C9 dependent metabolism of the anti-inflammatory and analgesic drug celecoxib. We found a seven-fold higher median exposure at steady-state in homozygous carriers of the CYP2C9*3 allele compared...
Nitric oxide in exhaled gas : studies on physiological regulation and measurements in infants and children
(1999-09-16)
Nitric oxide (NO) is found in the exhaled gas of humans, starting from birth, and is increased in adult patients with bronchial asthma. This study assessed whether the measurement of NO in exhaled gas is technically feasible ...
Finding synergies for cancer treatment : new ways to modulate DNA damage repair by CX3CR1 and PFKFB3 inhibition
(2021-06-01)
tissues. In this thesis, two cancer targets, CX3CR1 and PFKFB3, were investigated for their emerging roles in DNA repair. Furthermore, small molecule inhibitors KAN0438757, developed in Paper I to target PFKFB3, and KAND567 targeting CX3CR1, were evaluated...
Small artery dysfunction : focus on preeclampsia and end-stage renal disease
(2012-04-18)
Background: End-stage renal disease (ESRD) and preeclampsia (PE) are associated with high risk of cardiovascular events and characterized by endothelial dysfunction. Resistance arteries are actively involved in the control ...
Becoming a mother at an advanced age : pregnancy, outcomes, psychological distress, experience of childbirth and satisfaction with life
(2013-11-15)
The objectives of this thesis were to investigate adverse pregnancy outcomes, and pregnancy and psychological experiences in women who become mothers in the later phase of the reproductive period. The age of first-time ...