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Mechanism of conditional repression of human osteocalcin gene activity by glucocorticoids
(1998-04-06)
Bone is one of the major target sites of steroid hormone action. Steroid hormones like cortisol, vitamin D and estradiol are responsible for principle events associated with bone formation and resorption. The action of ...
Molecular studies of prognostic and etiological factors in childhood leukemia
(2015-04-29)
Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood. It is caused
by the somatic acquisition of genetic abnormalities and malignant transformation of
immature lymphocytes in the bone marrow, most ...
Effects of acute exercise and training on gene expression and regulatory proteins in human skeletal muscle
(2019-05-20)
Regular physical activity affects all tissues in the human body, not least skeletal muscle. The skeletal muscle adaptation involves changes that help the muscle to handle perturbations of the intracellular homeostasis ...
Detecting novel effects of exercise or AMPK activation in human skeletal muscle
(2018-04-24)
Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is adenosine ...
The bioenergetic roles of PGC-1α1, kynurenines, and GPR35 in exercise and obesity
(2021-11-09)
Obesity is a major cause of medical comorbidity with detrimental effects on health span. Fundamentally, obesity is a condition of disrupted energy metabolism, where energy intake chronically exceeds expenditure. Over time, ...
Exercise-induced molecular mechanisms in untrained and life-long highly trained individuals
(2020-08-21)
Regular physical activity results in extensive systemic and functional adaptation effects in the human body that contribute to physical performance, such as muscular strength and endurance, and can have beneficial health ...
Regulation of skeletal muscle metabolism and development by small, non-coding RNAs : implications for insulin resistance and type 2 diabetes mellitus
(2018-05-23)
microRNAs (miRNAs) are a class of epigenetic post-transcriptional regulators. These short (~22 nucleotides) non-coding RNAs can potently reduce protein abundance through direction of the RNA-induced silencing complex to ...
Regulatory networks of c-di-GMP signalling involved in biofilm formation, motility and host pathogen interactions in Salmonella typhimurium
(2013-08-09)
Adaptation to altered environmental conditions is one of the fundamental bacterial characteristics. The ubiquitous second messenger c-di-GMP plays a key role to adopt bacterial behaviour. Transition from motility to sessility ...
Pharmacological and analytical studies of the cyclin dependent kinase inhibitors
(2009-10-30)
Cyclin-dependent kinases (Cdks) play a key role in the regulation of cell cycle progression and RNA transcription. Deregulation of Cdks has been associated with several malignancies, neurodegenerative disorders, viral and ...
Intimate partner violence among women of reproductive age in Nigeria : magnitude, nature and consequences for reproductive health
(2011-01-05)
Background: Intimate Partner Violence (IPV) against women is now recognised as a problem of global magnitude, owing to its detrimental consequences on the health, social and economic welfare of women and their children. ...