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Breast cancer epidemiology : influence of hormone-related factors
(1998-03-27)
population-based case control study conducted in all of Sweden during October 1993 to March 1995. In this study 3,345 women aged 50-74 years with a diagnosis of primary breast cancer (84% of the eligible) and 3,454 age frequency-matched control women (82...
The cell cycle regulators p15, p16, p18 and p19 : functions and regulation during normal cell cycle and in multistep carcinogenesis
(2000-09-29)
The tumor suppressor protein p16INK4a and its family members p15INK4b, p18INK4c and p19INK4d (the INK4 proteins) inhibit the cyclin-dependent kinases CDK4 and CDK6, which are key regulators of the retinoblastoma protein ...
Assessment of psychological and social factors in the workplace : psychometric aspects
(2008-10-24)
Psychosocial aspects of work have received increasing attention, partly
because of their postulated importance for the workers health. Among the
techniques developed for measurement of the psychosocial work
environment, ...
Perks and considerations when targeting functional non-coding regions with CRISPR/Cas9
(2023-05-12)
with large-size CRISPR/Cas9 vectors. By co-transfecting small-size vectors (3 kb) to cells, the delivery efficiency of CRISPR/Cas9 vectors (15 kb) and cell viability was significantly increased. The performance of the method has been verified in a number...
Magnetic resonance imaging in chronic Achilles tendinopathy
(2004-03-05)
The main objective of this thesis was to evaluate and monitor the morphological response following treatment interventions in patients with chronic Achilles tendinopathy by using different MRI-techniques. For this purpose. ...
Endometriosis and ovarian reserve : inflammation and prognostic markers
(2008-04-18)
Introduction: Endometriosis is a common, benign gynecological disease,
associated with pelvic pain and infertility. It is generally thought to
be caused by retrograde shedding of menstrual tissue with subsequent
attachment ...
Mechanisms of adaptation to the fitness cost of antibiotic resistance
(2007-05-18)
The dissemination and persistence of antibiotic resistance, is not only
depending on the volume of drugs used but also on the resistance
mechanisms effect of bacterial fitness (reproductive ability). Fitness is
a multifactorial ...
Endometrial receptivity and regeneration in health and disease : molecular, cellular and clinical perspectives
(2022-02-25)
Each month, the endometrium regenerates under the influence of the ovarian hormones and builds up to a receptive state in preparation for embryo implantation. In the absence of pregnancy, it sheds during menses and the ...
Assays for monitoring HIV therapy in low-middle income countries
(2013-05-20)
and phylogenetic analysis with regard to transmitted drug resistance (TDR), subtype and the time of the most recent common ancestor (tMRCA). All strains belonged to HIV-1 CRF01_AE and TDR was found in 6.3% of the patients, including Y181C, L74I, V75M and L210W...
Mechanisms of women's own-gender bias and sex differences in memory for faces
(2012-09-06)
There are sex differences in some cognitive functions. For example, earlier studies have shown that women outperform men on face recognition tasks, and women, in contrast to men, show an own-gender bias (i.e., women typically ...