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Pathogenesis of arthritis in rats : genetic factors and inducing molecules
(1998-02-27)
such candidate, since it could induce autoimmune joint inflammation, as can collagen type II in the same rat strain. Both these forms of autoimmune arthritis were associated with a type 1 cytokine profile, while the type 2 cytokine IL-4 was produced in a...
Acute toluene effects on neurotransmission in the central nervous system
(1996-02-29)
The aim of this thesis was to develop a method to study the effects of toluene in the central nervous system of the rat. Microdialysis on awake rats was used to study toluene's effects on the transmission of dopamine, ...
Make it happen and make it matter : implementation and impact of primary healthcare-academia partnerships
(2019-09-26)
Introduction: Most patients’ health problems are initially managed within primary healthcare. Increasingly, current reforms in healthcare emphasize the important role of primary healthcare in the healthcare system. Therefore, ...
Assisted reproduction technology in men with ejaculatory dysfunction with special reference to spinal cord injury
(1998-05-16)
Background: Men afflicted by spinal cord injury (SCI), myelomeningocele (MMC) and testicular cancer (TC) with retroperitoneal lymph-node dissection (RPLND) share the problem of infertility due mainly, but not exclusively, ...
Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility
(2008-09-26)
lipoprotein receptor-related protein (LRP)/CD91. Interaction of TSP-1 with its cell surface receptors calreticulin (CRT), LRP and integrin associated protein (IAP)/CD47 was promoting motility of T cells in 3D collagen through CD47. T cell surface TSP-1 also...
Human leukocyte antigens with special reference to association and linkage in multiple sclerosis
(1997-11-28)
possibility to detect single nucleotide variations. One such HLA typing technique, PCR-amplification with sequence-specific primers (PCR-SSP), has been developed in our laboratory. The application of PCR-SSP for typing of the DQA1 locus and its use...
PET studies of the serotonin system in major depression and its treatment
(2014-10-03)
The serotonin system has been implicated in major depression since the
1960s, mainly based on the serotonin enhancing properties of
antidepressants. Positron emission tomography, PET, is the in vivo
molecular imaging ...
Heart failure : role of metabolic biomarkers, ejection fraction, and sex
(2018-10-30)
) To investigate whether HFpEF and HFrEF share features of anabolic impairment regarding insulin-like growth factor 1 (IGF-1) and IGF binding protein-1 (IGFBP-1). (2) To assess levels of the obesity related peptides, leptin and adiponectin, and whether the obesity...
Immune and autoimmune responses to HIV-1 in mucosa and other tissues
(1999-10-08)
mucosal route, jet-injection, for induction of systemic and local responses. This technique was found to be a rapid and easy way of administering plasmid DNA. A combination of the genes encoding the HIV-1 regulatory proteins rev, nef, tat...
Pathogenesis of type 2 diabetes with emphasis on the mechanism of insulin resistance
(2006-09-15)
of peroxisomal-proliferator-activated receptor (PPAR) γ co-activator 1 α (PGC-1α) increased in controls. No changes in the phosphorylation of AMP-activated protein kinase (AMPK) or acetyl CoA carboxylase (ACC) were seen. In conclusion, type 2 diabetes heredity...