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Hip fractures in the elderly : social, economic, and psychological aspects of rehabilitation
(1998-01-09)
Hip fracture is one of the most common somatic inpatient diagnoses, and its incidence will increase even further in the years to come. Since most subjects sustaining this kind of injury are old and living alone, the ...
T cells in solid tumors : investigating the immunomodulation in the tumor microenvironment
(2018-09-03)
The immune system protects human from cancer through an immunosurveillance mechanism. However, the progressive nature of tumor cells to differentiate and the complexity of the tumor microenvironment may result in the ...
Adaptive immunity in urothelial cancer : molecular and clinical aspects
(2018-10-05)
In the battle between the immune system and cancer, tolerance mechanisms otherwise protective against autoimmunity, are exploited to halt the anti-tumor immune response. In this model, tumors turn distinct parts of the ...
Studies on the regulatory roles of cholesterol and bile acids
(2007-05-04)
of transcription factors such as the sterol regulatory element binding
proteins (SREBP), the liver X receptor and the farnesoid X receptor.
A Cyp8b1 knockout mouse model has been created, which lacks the ability
to synthesize CA. Using this model we investigated...
Molecular and epidemiological studies of bladder exstrophy and epispadias complex
(2023-04-13)
was utilized to detect submicroscopic copy number variants in 140 affected Swedish individuals. The most interesting novel finding was a maternally inherited microdeletion in chromosome Xq23 in a male individual, indicating an X-linked recessive inheritance...
Progression of RNA-sequencing to single-cell applications
(2014-05-02)
New methods enable new discoveries. My time as a PhD student has run in parallel with the maturation of the RNA-seq method, and I have used it to discover basic properties of gene expression and transcriptomes. My part has ...
Diagnosis and treatment of Helicobacter pylori infection in Vietnamese children
(2009-11-20)
Aim: The aim of the study was to find the optimal H. pylori eradication therapy for children in Vietnam, a developing country. Therefore, we evaluated a non-invasive diagnostic method and antibiotic susceptibility of H. ...
Circulating immune complexes in atherosclerotic vascular disease
(2001-08-31)
We have investigated the association of the humoral immune factors
circulating immune complexes (CICs) and autoantibodies against
cardiolipin (aCL) and oxidatively modified LDL (oxLDL) to atherosclerotic
vascular diseases.
In ...
Dietary effects on gene regulation and function in human adipose tissue in obesity
(2007-05-04)
-A interacts with the liver X receptors (LXRs) in human adipocytes. We also found that activation of the LXRs stimulates lipolysis, possibly via down-regulation of perilipin. We suggest that CIDE-A mediates its antilipolytic effect via modulation of LXR...
To catch a killer : on the mechanisms of interferon alpha induced apoptosis
(2005-01-28)
A major clinical problem regarding treatment of malignant tumours is primary or secondary resistance to therapy. Anti-tumour drugs act primarily by induction of apoptosis. However, the knowledge of how various substances ...