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HIV-1 patient assessment and treatment : from multitest to co-receptor (CCR5) gene polymorphism : from Rgp160 immunization to highly active antiretroviral treatment (HAART)
(1998-01-02)
G increases over time and may be used as an approximate marker of the length of infection. Oligoclonal bands were typically seen in serum. These findings fit a model of a change in immune balance favouring Th2 over Thl responses.
Although HIV-1 obviously...
Prospective cohort studies of disability pension and mortality in a Swedish county
(2007-09-04)
The overall aim of this thesis was to study risk factors for disability
pension, focusing on sociodemographic risk factors and sick-leave
diagnoses, and also to investigate the risk of mortality among disability
pension ...
Pathogenesis of type 2 diabetes with emphasis on the mechanism of insulin resistance
(2006-09-15)
Type 2 diabetes is characterized by chronic hyperglycemia and develops slowly through stages of early impairments of glucose metabolism. The disease is often associated with obesity, physical inactivity, decreased insulin sensitivity and impaired...
Regulation of mitosis : molecular analysis of the anaphase-promoting complex
(2000-11-10)
/G1 respectively. The Cdc20 is also known to interact with the spindle assembly checkpoint through a protein called Mad2. The mammalian APC/C consists of at least eleven subunits, for most of which the specific function is still unknown. Apc2 contains...
Treatment of uncomplicated malaria in Guinea-Bissau
(2006-03-10)
line treatment for uncomplicated malaria to 50 mg/kg bodyweight of CQ could be implemented easily and without delay. 2) The use of S/P should be limited, but it can be used as second line therapy. 3) AQ could be reserved as the partner drug in a future...
Signal processing approaches on otoacoustic emissions
(2000-09-29)
The recent achievement on the measurement of otoacoustic emissions (OAEs) is based on a novel technical development of digital signal processing. OAEs measured in the external ear canal are normal by-products of the active ...
Cisplatin-induced tumor cell death signaling and potentiation by energy metabolism inhibitors
(2007-01-05)
, the effects of sensitizing tumor cells to cisplatin by inhibition of their energy production are investigated. Both an inhibitor of glycolysis, 2-deoxyglucose (DG) as well as an inhibitor of fatty acid â oxidation, etomoxir, were shown to potentiate...
Extremely preterm birth : brain imaging and outcome at early school-age
(2018-05-09)
There has been a dramatic increase in the survival of extremely preterm children over the last decades, and the awareness of the consequences of extremely preterm birth on the developing brain is increasing. This thesis ...
Synthetic pulmonary surfactant : effects of surfactant proteins B and C and their analogues
(2010-08-19)
Pulmonary surfactant is a lipid/protein mixture lining the air-liquid
interface in the alveoli. Its main function is to lower surface tension
during respiration and thereby prevent alveolar collapse at
end-expiration. ...
Modelling depression in animals and the potential antidepressant effect of histaminergic modulation
(2015-05-22)
Depression is at the top position for "years lived with disability" (Smith, 2014). Its aetiology
is unknown, but the pathogenesis implicates changes in glutamatergic neuronal plasticity.
Glutamatergic plasticity likely ...