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Regulation of insulin-like growth factor binding protein-1 (IGFBP-1) and implications in catabolic conditions
(1997-09-24)
This thesis has studied the regulation of IGFBP-1 (insulin-like growth factor binding protein 1), which is one factor regulating the bioavailability of IGF-I with special interest how IGFBP-1 is regulated in vitro and in ...
Effects of starvation and haemorrhage on the large bowel coliform flora with special reference to bacterial mucosal adherence and translocation
(1997-12-19)
Intestinal bacteria translocating to extra-intestinal sites have been suggested to play a role in the etiology of posttraumatic infections and multiple organ failure. In the present study, effects of haemorrhagic stress ...
Genetic study of autosomal dominant progressive external ophthalmoplegia and familial myasthenia gravis : linkage analysis, candidate gene cloning and mutation detection
(2001-03-09)
Identification of genes responsible for familial human diseases is a major task of medical genetics. In this process, linkage analysis, candidate gene screening and mutation detection are the three major steps (Paper I-VI). ...
Understanding structure and function of membrane protein transporters
(2008-11-28)
Membrane protein transporters are important proteins in the cell, as they maintain different solutes and metabolites at a stable concentration. Numerous diseases can be linked to malfunctioning transporters, which makes ...
Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility
(2008-09-26)
of MMPs (TIMP-1) and ability to infiltrate a threedimensional (3D) gel of extracellular (ECM) components. However, cell migration to two-dimensional (2D) ECM-components was not correlated to MMP-9/TIMP-1 expression. The role for MMP-9 and TIMP-1...
Long-term follow-up after treatment of invasive and in situ breast cancer : aspects on second breast cancers HRQOL and lymphoedema
(2014-02-28)
Breast cancer is the most frequent cancer among Swedish women and in 2012, 8490 new inva- sive breast cancers were diagnosed. The incidence of in situ breast cancer has markedly in- creased since nationwide mammography ...
Statistical methods for the detection, analyses and integration of biomarkers in the human genome and transcriptome
(2014-09-09)
Most human diseases have been shown to have a genetic basis that is linked to regulation of gene expression at the transcriptional or post-transcriptional level. In the central dogma of biology, deoxyribonucleic acid (DNA) ...
Cell cycle and differentiation in Giardia Lamblia
(2008-04-30)
Giardia lamblia is the major cause of waterborne diarrhea worldwide.
Giardiasis is initiated by ingestion of cysts, which after passing
through the stomach are triggered to excyst. Excystation, or awakening
from dormancy, ...
Diabetic osteopathy : a study in the rat
(2012-03-09)
The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 ...
Visualizing the dynamic interplay between the host and bacterial pathogen : a real-time study of renal infection
(2007-05-10)
The human body is a complex entity capable of handling a variety of
pathogenic challenges without developing disease symptoms. Sometimes,
however, the pathogens are superior and the host immune system is unable
to clear ...