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Basal lamina genes affected in leiomyomatosis and congenital muscular dystrophy : structure and mutation analyses of the collagen COL4A6 and laminin LAMA2 genes
(1997-11-21)
in diseases such as Alport syndrome, leiomyomatosis, and also their possible role in congenital muscular dystrophy, the complete exon intron structure of the gene for the human type IV collagen a6 chain (COL4A6) and laminin a2 chain (LAMA2) were determined...
Presence of extrathyroidal TSH-receptor, with special reference to its role in neonatal regulation of lipolysis
(1998-03-13)
At birth, the newborn child must utilize stored energy until lactation is established. The main source of energy is fat - that is, triglycerides stored in the white adipose tissue. This study deals with hormonal regulation ...
Molecular characterization of phenothiazines in experimental cancer therapy : new tricks of an old drug revealed
(2012-04-04)
Cancer is characterized by uncontrolled malignant proliferation of cells that eventually interfere with tissue/organ functions. Traditionally, cancer is treated with chemo- and/or radiotherapy when surgery is not an option. ...
Leukotriene A4 hydrolase : identification of amino acid residues involved in catalyses and substrate-mediated inactivation
(2001-09-14)
Leukotriene (LT) A4 hydrolase catalyzes the committed step in the
biosynthesis of LTB4, a classical chemoattractant and immuine-modulating
lipid mediator involved in inflammation, host-defense against infections,
and ...
Finding synergies for cancer treatment : new ways to modulate DNA damage repair by CX3CR1 and PFKFB3 inhibition
(2021-06-01)
The goal of targeted cancer therapy is to selectively kill cancer cells based on their molecular survival mechanisms. DNA repair is as a promising cancer target as many cancers have chronic replication stress and deficiencies ...
Fat mass, adipokines and clinical complications of chronic kidney disease
(2006-05-26)
Patients with chronic kidney disease (CKD), irrespective of initial etiology, have a risk of cardiovascular morbidity (CVD) and mortality that is many-fold higher than that of a similar person without CKD. While traditional ...
Mechanisms of chronic complications of diabetes with focus on mitochondria and oxygen sensing
(2009-12-25)
Chronic complications of diabetes represent a major medical and economical concern. It is an imperative need to establish the pathogenic mechanisms that contribute to development of chronic complications in order to design ...
Yogaträning för barn med cerebral pares : ledrörlighet och muskelelasticitet i nedre extremiteterna
(2015-06-16)
Background: Movement and posture are always affected in children with cerebral palsy (CP). Motor symptoms vary in degree and severity, however a decreased joint mobility in the lower extremities is common. With increasing ...
Epidemiological characterisation of Bordatella pertussis in Sweden, 1970-2004
(2007-01-26)
Worldwide, Bordetella pertussis causes some 50 million cases of pertussis, and an estimated 2-300,000 fatalities each year. In Sweden vaccination against pertussis was introduced in the 1950s using diphtheria-tetanus-whole-cell ...
Elucidating regulatory elements : studies in chronic lymphocytic leukemia and multiple myeloma
(2018-12-21)
background, they might present with a common epigenetic background. For this we aimed to collect paired RNA-seq, histone ChIP-seq and ATAC-seq for patients and healthy controls, and had the following specific hypotheses: 1. Using H3K4me2 and H3K27Ac, we...