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Transurethral microwave thermotherapy of benign prostatic hyperplasia : a clinical and methodological evaluation
(1997-11-14)
Transurethral microwave thermotherapy (TUMT) is a relatively new type of treatment for symptomatic benign prostatic hyperplasia. The aim of this study was to evaluate different aspects of TUMT such as catheter characteristics, ...
Fine needle aspiration cytology in diagnosis and management of childhood small round cell tumours
(1999-12-24)
for the diagnostic EWS gene (22q12) rearrangement in Ewing's sarcoma/peripheral primitive neuroectodermal tumours (pPNET). FNA cytology correctly diagnosed and classified 85/94 patients (90.4%) with SRCTs at primary disease into lymphoma (27/27: B-cell lymphoma 9...
Mechanisms of cell type-specific gene transcription : studies on the choline acetyltransferase gene
(1998-05-06)
Choline acetyltransferase (ChAT) is the enzyme synthesizing the neurotransmitter acetylcholine. Previous studies from our laboratory on the regulation of the cholinergic phenotype have suggested the presence of regulatory ...
Translational studies of drug-induced tumor cell death
(2006-09-29)
It is essential to understand the mechanisms of action of anticancer drugs in order to obtain good treatment results. I have in the present thesis studied clinically used anticancer agents as well as other agents that ...
Unifying viral evolution and immunological patterns to investigate risk of HIV-1 disease progression
(2012-11-27)
, HIV-1 in vivo evolution and epitope-specific CD8+ T cell responses were investigated in six untreated HLA-B*5701 patients monitored from early infection up to seven years post-infection. The subjects were classified as high-risk progressors (HRPs...
Biosynthesis of leukotriene B4 in hematological malignancies
(2005-05-27)
Leukotrienes (LT) are biologically active metabolites of the fatty acid
arachidonic acid (AA). After liberation of AA by phospholipase A 2 (PLA
2), this fatty acid can be converted to leukotrienes, lipoxins,
prostaglandins ...
Novel in vitro methods aiming at improving fertility preservation
(2021-11-11)
group and the strongest apoptotic signals on histological assessment were also found at 24 h, and there was transcriptional up-regulation of apoptosis related genes (Noxa, Bax, Casp 6 and 8) while Tap63 was down-regulated. There was no evidence...
Delivery of DNA vaccines against cancer
(2006-10-06)
/DNA vaccine we investigated a new delivery method, in vivo electroporation (EP). When injecting the DNA vaccine intradermally and applying a short sequence (~ 3 sec) of optimized electrical pulses, the number of induced PSA-specific CD8+ T cells was greatly...
Pursuing the fever trail : pathogenesis of blood-stage P. falciparum malaria and pregnancy
(2008-05-19)
The burden of the most virulent form of human malarias, Plasmodium
falciparum, is concentrated among young children and pregnant women in
sub-Saharan Africa. Excessive sequestration of parasite-infected red
blood cells ...
Methodological aspects on carotid artery intervention
(2017-02-17)
. Study II revealed that it was safe to perform CAS early (within 1 week), following a TIA/stroke. The stroke and death rate for patient treated within 7 days from neurologic symptom was 4.1%, compared to 6.3% between day 8-14, 4.8% between day 15...