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Development of radioligands for emission tomography imaging of dopamine D1 and benzodiazepine receptors
(1997-08-15)
Brain imaging of dopamine and benzodiazepine (BZ) receptors in vivo is of central interest in neuropsychiatric disorders such as schizoprenia, Huntington's disease and epilepsy.
The objective was to develop new ...
Molecular epidemiology of tuberculosis
(2011-11-09)
Tuberculosis is a global epidemic, with one third of the world’s population estimated to be infected, around 9 million new active cases per year and close to 2 million deaths per year. Without adequate chemotherapy tuberculosis may be a mortal...
Bone marrow mesenchymal stem and progenitor cells in myeloid malignancies
(2017-10-24)
Hematopoietic stem cells (HSCs) reside in bone marrow (BM) microenvironment / niche to
self-renew and generate all types of mature blood cells in postnatal life. This process is called
hematopoiesis. Normal hematopoiesis ...
Regulation of mitosis : molecular analysis of the anaphase-promoting complex
(2000-11-10)
/G1 respectively. The Cdc20 is also known to interact with the spindle assembly checkpoint through a protein called Mad2. The mammalian APC/C consists of at least eleven subunits, for most of which the specific function is still unknown. Apc2 contains...
Regional pulmonary vasoreactivity, with special reference to nitric oxide, prostacyclin and body posture
(2009-10-02)
RNA for endothelial NO synthase (eNOS) was higher in dorsal compared to ventral human lung regions. Ca2+-dependent NOS activity was higher in dorsal than in ventral regions of both human and porcine lungs. Relaxation of porcine pulmonary arteries in vitro...
Synaptic uncoupling in the mouse cochlea induced by noise or cisplatin and its clinical relevance
(2020-03-12)
to the direct impact of cisplatin on the clock machinery since the administration of cisplatin on ex-vivo cochleae at nighttime altered the rhythms of the clock protein Period2 in a dose dependent manner. A meta-analysis identified five genes that are associated...
Molecular and epidemiological studies of bladder exstrophy and epispadias complex
(2023-04-13)
Bladder exstrophy and epispadias complex is a rare congenital genitourinary malformation involving a midline closure defect, leaving an open bladder on the lower abdominal wall.
In Sweden, the prevalence is 3:100 ...
A 10-year follow-up of people with multiple sclerosis-aspects of disability and health, use of and satisfaction with care, and feasibility of cognitive behavioural therapy
(2014-11-21)
Background: Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease in the central nervous system which affects a number of life areas of the afflicted individual. Detailed knowledge is required on ...
PET studies of the serotonin system in major depression and its treatment
(2014-10-03)
The serotonin system has been implicated in major depression since the
1960s, mainly based on the serotonin enhancing properties of
antidepressants. Positron emission tomography, PET, is the in vivo
molecular imaging ...
Molecular mechanisms of cardiovascular calcification
(2019-05-23)
Cardiovascular calcification is a pathophysiological process characterized by the deposition of calcium-phosphate crystals in the arteries and the leaflets of the heart valves. In the arteries calcification causes arterial ...