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Health-related quality of life and patient education in a group of uremic patients
(1997-08-15)
The main purpose of this thesis was firstly, to describe a group of uremic patients' health-related quality of life (HRQOL) prior to and after having started dialysis and secondly, their HRQOL after participation in a ...
Associations of breast cancer risk prediction tools with tumor characteristics and metastasis
(2020-04-23)
Purpose: The association between established risk factors for breast cancer and subtypes or prognosis of the disease is not well known. We analyzed whether the Tyrer-Cuzick–predicted 10-year breast cancer risk score (TCRS), ...
Novel skeletal stem and progenitor cells and their regulation
(2022-01-20)
The development of bone and cartilage, which provide the framework of the skeletal system,
is complex. In this context stem and progenitor cells play a crucial role by producing
differentiated cells. Hormones are important ...
To catch a killer : on the mechanisms of interferon alpha induced apoptosis
(2005-01-28)
A major clinical problem regarding treatment of malignant tumours is primary or secondary resistance to therapy. Anti-tumour drugs act primarily by induction of apoptosis. However, the knowledge of how various substances ...
Musculoskeletal injuries and generalized joint laxity in ballet dancers
(2012-09-13)
students (11 boys, 12 girls) in 4th grade at the Royal Swedish Ballet School in Stockholm, and 36 controls at a public Swedish school were examined regarding spinal configuration in standing. The spinal sagittal mobility was measured by use of De Brunner’s...
Epstein-Barr virus and genomic instability : a new look at the mechanisms of viral oncogenesis
(2010-12-20)
EBV is associated with a variety of lymphoid and epithelial malignancies but the mechanisms of oncogenesis are still not fully understood. The aim of the work described in this thesis was to assess whether induction of ...
Analysis of phenotype reversibility in Hutchinson-Gilford progeria syndrome in mice
(2017-04-12)
Aging affects all people and is a complex process involving both genetic and environmental factors in a way that is not yet completely understood. Studies of premature aging syndromes might be helpful to acquire further ...
Visualizing the dynamic interplay between the host and bacterial pathogen : a real-time study of renal infection
(2007-05-10)
The human body is a complex entity capable of handling a variety of
pathogenic challenges without developing disease symptoms. Sometimes,
however, the pathogens are superior and the host immune system is unable
to clear ...
Immunological alterations, therapies with immune check-point inhibitors and beyond in patients with metastatic melanoma
(2020-10-07)
in the immune system, in addition to those related to T-cells, during treatment with anti-CTLA 4 and anti-PD1 antibodies. In addition, we conducted a phase I trial with adoptive T cell therapy (ACT) with or without dendritic cell (DC) vaccination...
Persistent inflammatory pathways in rheumatoid arthritis despite anti-rheumatic treatment
(2010-11-18)
immune interactions and inflammation, in which prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) are important players and contributors to pathogenesis. Our research aimed to investigate the synovial expression of enzymes controlling prostaglandin E2...