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Humoral immunity to recombinant human autoantigens in organ-specific autoimmune disease
(1996-05-29)
Insulin-dependent diabetes mellitus (IDDM) and idiopathic Addison's disease are organ-specific autoimmune diseases characterized by the presence of circulating autoantibodies. The role of autoantibodies in the pathogenesis ...
Integrated assessment of environmental and human health risks of antibiotic residues and resistance for environmental and health policy
(2021-04-27)
Background: Antibiotic resistance is a global health crisis and a serious threat to progress in achieving the Sustainable Development Goals. This requires a One Health response that recognises the link between human and ...
Predicting and monitoring disease course in rheumatoid arthritis : imaging, biomarkers, risk factors, and integrative medicine
(2017-04-28)
Rheumatoid arthritis (RA), the most common inflammatory arthritis, is a chronic, potentially debilitating autoimmune disease that can lead to functional disability, bone erosion, and chronic pain. The modern era of treatment ...
Toxicity of metal and metal oxide nanoparticles : the importance of physicochemical properties and cellular uptake
(2012-10-04)
The use of nanoparticles holds great promises in many technical as well as medical applications. However, development of new technologies, such as nanotechnology, is connected with uncertainties and risks. The same properties ...
Platelet function in diabetes mellitus : relationships to hyperglycaemia, antidiabetic treatment and microangiopathy
(2005-01-14)
Diabetes mellitus is associated with accelerated atherosclerosis and increased morbidity and mortality in micro-and macrovascular complications. The metabolic derangements that accompany diabetes can adversely influence ...
AB0-incompatible kidney transplantation using antigen-specific immunoadsorption and rituximab
(2008-03-21)
5As the demand for kidney transplantation is constantly growing methods to expand the donor pool have become increasingly important. AB0-incompatibility has hitherto been regarded as an absolute contraindication to living donor donation. However...
Mortality and co-morbidity among patients with hemochromatosis and their first-degree relatives
(2010-05-14)
Genetic hemochromatosis (GH) is an autosomal recessive disease caused by
a C282Y mutation in the HFEgene, and is characterized by excess iron
accumulation in multiple organs. Classical manifestations of GH include
liver ...
Oxidative stress and age-related cataract
(2015-09-04)
Age-related cataract is a clouding of the lens that leads to decreased vision. It increases with age and is one of the leading causes of blindness worldwide. The only treatment currently available is surgery. Therefore, ...
Elevated fasting glucose levels in obese children and adolescents : prevalence and long-term consequences
(2016-01-29)
, regardless of gender and ethnicity. While the WHO-defined IFG predicted future use of T2DM medication in early adulthood with an adjusted hazard ratio of 3.84 compared with those who had fasting glucose levels <5.6mmol/L. A fasting glucose level of 5.6-6.0...
Demand and capacity imbalance in the emergency department, and patient outcomes
(2021-02-16)
) between mean ED LOS and mean emergency ward bed occupancy of 0.94 (0.55 – 0.99). Aim 3) Study II identified a statistically significant association between crowding and 30-day mortality with an estimated HR (95% CI) of 1.08 (1.03-1.14) in the high category...